Table 3.
Multivariate Cox regression for SPT development. Table 3 shows the results of the multivariate Cox regression of SPT (0 = no SPT, 1 = SPT) on the independent variables of tumor HPV positivity (negative = 0, positive = 1), smoking status (0 = <10 py, 1 = ≥10 py), history of alcohol abuse (0 = no alcohol abuse, 1 = alcohol abuse), age (in years), sex (0 = male, 1 = female), UICC stage (1 = stage I, 2 = stage II, 3 = stage III, 4 = stage IVa, 5 = stage IVb), and therapy mode (0 = surgery only, 1 = RT ± chemo). * indicates statistical significance at the 5% significance level. Since alcohol use is unknown in three patients, 88 observations are included instead of 91. Abbreviations: Chemo = chemotherapy, CI = confidence interval, HR = hazard ratio, py = pack years, RT =radiotherapy, UICC = Union internationale contre le cancer.
| Multivariate Cox Regression for SPT Development | SPT Development | |
|---|---|---|
| Parameter | HR (95% CI) |
p-Value |
| Tumor HPV-positivity | 0.362 (0.155–0.847) |
0.019 * |
| Smoking (>10 py) | 0.723 (0.239–2.190) |
0.566 |
| Alcohol abuse | 0.995 (0.456–2.170) |
0.989 |
| Age | 0.981 (0.940–1.023) |
0.365 |
| Gender | 0.370 (0.092–1.488) |
0.161 |
| UICC stage | 0.908 (0.659–1.251) |
0.556 |
| Therapy mode | 0.911 (0.403–2.058) |
0.823 |
| Number of observations | 88 | |