Table 7.

Overview over localization and histological entity of the tumors of HPV-positive and HPV-negative patients who developed an SPT.

HPV Positivity	Localization of Index Tumor	Localization SPT	Histology of SPT
Positive	tonsil	lung	Squamous cell carcinoma, with growth pattern distinct from index tumor
	Tonsil	Lung	Squamous cell carcinoma
	Base of tongue (right)	Vallecula (left)	Squamous cell carcinoma
	Base of tongue	Lung	Small cell lung carcinoma
	Oropharynx	Lung	Squamous cell carcinoma
	Tonsil	Vocal cord	Squamous cell carcinoma
	Tonsil	Side of the tongue	Squamous cell carcinoma
	Tonsil (left)	Tonsil (right)	unknown
Negative	Oropharynx	Thyroid gland	Papillary thyroid carcinoma
	Oropharynx	Side of the tongue	Squamous cell carcinoma, p16-negative
	Oropharynx	Lung	adenocarcinoma
	Tonsil	Base of tongue	Squamous cell carcinoma, p16-negative
	Tonsil (right)	Vallecula (left)	Squamous cell carcinoma
	Oropharynx	Soft palate	High grade dysplasia
	Base of tongue (right)	Larynx (left)	Squamous cell carcinoma
	Tonsil (left)	Hypopharynx (right)	Squamous cell carcinoma
	Tonsil	Lung	Squamous cell carcinoma
	Tonsil	Hypopharynx	Squamous cell carcinoma
	Tonsil (right)	Tonsil (left)	Squamous cell carcinoma (p16-positive)
	Tonsil	Hypopharynx	Squamous cell carcinoma
	Tonsil	Esophagus	Squamous cell carcinomas/adeno