Table 4.
Comparison of liver tests improvement ≥50% and <50% after 1 week (±2 days) of AIHPAs treatment.
| Variable (mean ± SD, n(%)) | Liver tests improvement after 1 week (±2 days) AIHPAs treatment | t/U/χ2 | p | |
|---|---|---|---|---|
| ≥50% | <50% | |||
| Age (years) | 47.33 ± 13.69 | 51.21 ± 16.17 | -1.170 | 0.245 |
| The first set of ALT level (IU/L) | 795.58 ± 644.66 | 256.26 ± 211.60 | 237.500 | ≤0.001 |
| The first set of ALP level (IU/L) | 185.55 ± 124.16 | 401.51 ± 294.86 | 1277.500 | ≤0.001 |
| The first set of TBIL level (μmol/L) | 82.26 ± 108.19 | 57.56 ± 69.99 | 672.500 | 0.226 |
| Gender | ||||
| Male | 26 (31.70) | 18 (21.95) | 0.012 | 0.913 |
| Female | 22 (26.83) | 16 (19.51) | ||
| Types | ||||
| Hepatocellular | 44 (53.66) | 7 (8.54) | 46.653 | ≤0.001 |
| Cholestatic | 3 (3.66) | 21 (25.61) | ||
| Mixed | 1 (1.22) | 6 (7.32) | ||
| Severity of DILI and HILI | ||||
| Grade 1 | 28 (34.57) | 23 (28.40) | 0.560 | 0.454 |
| Grade 2 | 9 (11.11) | 4 (4.94) | ||
| Grade 3 | 5 (6.17) | 6 (7.41) | ||
| Grade 4 | 5 (6.17) | 1 (1.23) | ||
| Treatment by AIHPAs | ||||
| Monotherapy | 5 (6.10) | 3 (3.66) | 0.746 | 0.388 |
| Combination with 2 drugs | 12 (14.63) | 14 (17.07) | ||
| Combination with drugs ≥3 | 31 (37.80) | 17 (20.73) | ||