Table 2.

Clinical evidence linking vitamin K2 supplementation and bone health.

Study	Type of the Study	Number of Patients Enrolled	Key Findings
[85]	RCT	219 post-menopausal women	BMD increase following one year of vitamin K2 supplementation (100 μg/day)
[86]	RCT	244 healthy post-menopausal women	Decrease bone loss following three years MK-7 supplement (180 μg/day)
[87]	Meta-analysis of 19 RCTs	6759 participants (post-menopausal women)	BMD improvement and low incidence of fracture in osteoporotic subjects following K2 treatment
[88]	Meta-analysis of 36 RCTs	11,122 participants (post-menopausal women)	Vitamin K2 treatment (MK-4: 45 mg/day) reduce fracture, increase cOC and decrease ucOC serum concentration
[89]	RCT	55 healthy children	8 weeks MK-7 supplementation increase cOC serum concentration
[90]	Non-placebo-controlled dose-examination study	55 healthy males	MK-4 supplementation (600 and 900 μg/day) decrease ucOC and increase cOC level respectively
[91]	RCT	48 healthy post-menopausal women	Serum ucOC concentrations were significantly lower following 6–12 months MK-4 treatment (1.5 mg/day)
[92]	RCT	60 postmenopausal women	MK-7 treatment (100 μg/day) significantly decrease ucOC and increase cOC/ucOC ratio