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. 2021 Apr 7;10(4):401. doi: 10.3390/antibiotics10040401

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dihydrofolate reductase chain A (right) from S. aureus in complex with trimethoprim (green) and NADPH (orange) and dihydropteroate synthase chain B (left) from Y. pestis in complex with sulfamethoxazole (green) and 6-hydroxymethylpterin-diphosphate (orange). The figure was built with Biovia Discovery Studio 4.1 using the PDB entries 3TZF and 2W9S [40,41].