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. 2021 Apr 7;10(4):401. doi: 10.3390/antibiotics10040401

Table 1.

Antibiotics’ classification by the mechanism of action.

Antibiotic Class Target Site Representatives
β-lactams Penicillins Cell wall synthesis Penicillin G and Penicillin V, Methicillin, Oxacillin, Cloxacillin, Dicloxacillin, Nafcillin, Ampicillin, Amoxicillin, Carbenicillin, Ticarcillin, Mezlocillin, Piperacillin, Azlocillin, Temocillin
Cephalosporins Cell wall synthesis 1st generation: Cephalothin, Cephapirin, Cephradine, Cephaloridine, Cefazolin
2nd generation: Cefamandole, Cefuroxime, Cephalexin, Cefprozil, Cefaclor, Loracarbef, Cefoxitin, Cefmetazole
3rd generation: Cefotaxime, Ceftizoxime, Ceftriaxone, Cefoperazone, Ceftazidime, Cefixime, Cefpodoxime, Ceftibuten, Cefdinir
4th generation: Cefpirome, Cefepime
5th generation: Ceftaroline, Ceftobiprole
Carbapenems Cell wall synthesis Imipenem, Meropenem, Doripenem
Monobactams Cell wall synthesis Aztreonam
Macrolides Protein synthesis inhibitors—Inhibit 50 s subunit Erythromycin, Azithromycin, Clarithromycin
Tetracyclines Protein synthesis inhibitors—Inhibit 30 s subunit Tetracycline, Chlortetracycline, Oxytetracycline, Demeclocycline, Minocycline, Methacycline, Doxycycline, Tigecycline
Aminoglycosides Protein synthesis inhibitors—Inhibit 30 s subunit Streptomycin, Neomycin, Kanamycin, Paromomycin, Gentamicin, Tobramycin, Amikacin, Netilmicin, Spectinomycin, Sisomicin, Isepamicin
Sulfonamides Folic acid synthesis inhibitors Prontosil, Sulfonamide, Sulfanilamid, Para-Aminobenzoic Acid, Sulfadiazine, Sulfisoxazole, Sulfamethoxazole, Sulfathalidine
Quinolones DNA synthesis inhibitors Nalidixic Acid, Ciprofloxacin, Norfloxacin, Pefloxacin, Enoxacin, Ofloxacin, Levofloxacin, Sparfloxacin, Lomefloxacin, Fleroxacin
Izoniazid Mycolic acid synthesis inhibitors
Ansamycin RNA synthesis inhibitors Rifampin
Polymycins Cytoplasmic membrane structure
Daptomycin Cytoplasmic membrane structure