Table 1.
Antibiotic Class | Target Site | Representatives | |
---|---|---|---|
β-lactams | Penicillins | Cell wall synthesis | Penicillin G and Penicillin V, Methicillin, Oxacillin, Cloxacillin, Dicloxacillin, Nafcillin, Ampicillin, Amoxicillin, Carbenicillin, Ticarcillin, Mezlocillin, Piperacillin, Azlocillin, Temocillin |
Cephalosporins | Cell wall synthesis |
1st generation: Cephalothin, Cephapirin, Cephradine, Cephaloridine, Cefazolin 2nd generation: Cefamandole, Cefuroxime, Cephalexin, Cefprozil, Cefaclor, Loracarbef, Cefoxitin, Cefmetazole 3rd generation: Cefotaxime, Ceftizoxime, Ceftriaxone, Cefoperazone, Ceftazidime, Cefixime, Cefpodoxime, Ceftibuten, Cefdinir 4th generation: Cefpirome, Cefepime 5th generation: Ceftaroline, Ceftobiprole |
|
Carbapenems | Cell wall synthesis | Imipenem, Meropenem, Doripenem | |
Monobactams | Cell wall synthesis | Aztreonam | |
Macrolides | Protein synthesis inhibitors—Inhibit 50 s subunit | Erythromycin, Azithromycin, Clarithromycin | |
Tetracyclines | Protein synthesis inhibitors—Inhibit 30 s subunit | Tetracycline, Chlortetracycline, Oxytetracycline, Demeclocycline, Minocycline, Methacycline, Doxycycline, Tigecycline | |
Aminoglycosides | Protein synthesis inhibitors—Inhibit 30 s subunit | Streptomycin, Neomycin, Kanamycin, Paromomycin, Gentamicin, Tobramycin, Amikacin, Netilmicin, Spectinomycin, Sisomicin, Isepamicin | |
Sulfonamides | Folic acid synthesis inhibitors | Prontosil, Sulfonamide, Sulfanilamid, Para-Aminobenzoic Acid, Sulfadiazine, Sulfisoxazole, Sulfamethoxazole, Sulfathalidine | |
Quinolones | DNA synthesis inhibitors | Nalidixic Acid, Ciprofloxacin, Norfloxacin, Pefloxacin, Enoxacin, Ofloxacin, Levofloxacin, Sparfloxacin, Lomefloxacin, Fleroxacin | |
Izoniazid | Mycolic acid synthesis inhibitors | ||
Ansamycin | RNA synthesis inhibitors | Rifampin | |
Polymycins | Cytoplasmic membrane structure | ||
Daptomycin | Cytoplasmic membrane structure |