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. 2021 Apr 7;13(8):1766. doi: 10.3390/cancers13081766

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HVEM surface expression is decreased on leukemic cells from patients with CLL. HVEM expression was evaluated on leukemic cells from patients with CLL (n = 46) and B cells from HD (n = 20) by flow cytometry. Representative histogram (A) and comparison (B) of HVEM expression on leukemic and B cells from patients with CLL and controls (MFI ± SEM) are shown. Comparison of HVEM surface expression in patients stratified by Rai stage (C) and Binet stage (D) (MFI ± SEM) are depicted. (E) Microarray data from the GEO database were employed to determine HVEM mRNA expression in patients with CLL regarding HD (GSE22529). (F) HVEM mRNA levels were evaluated according to leukemic cell localization (GSE21029). * p < 0.05, ** p < 0.01.