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. 2021 Apr 7;9(4):398. doi: 10.3390/biomedicines9040398

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Biochemical and histopathological analyses of a mouse model of adenine diet-induced CKD. Renal function was evaluated by analyzing blood urea nitrogen (BUN) (A) and creatinine (B) levels (five mice per group). * p < 0.05 compared with the normal group. # p < 0.05 compared with the CKD group. Data are presented as the means ± standard deviation. Representative micrographs of H&E (C) and Masson’s trichrome (D) staining in the indicated groups in the adenine diet-induced CKD model. Scale bar = 60 µm.