Table 1.
Demographic and clinical characteristics of patients with favorable and unfavorable outcomes
| Total (n = 259) | Favorable outcome (MRS 0–2) (n = 232) | Unfavorable outcome (MRS 3–6) (n = 27) | P-value | |
|---|---|---|---|---|
| MRS | 0(0–1) | 3(3–4) | < 0.001 | |
| Age (yr) | 65.3±12.5 | 64.7±12.7 | 70.1±9.0 | 0.033 |
| NIHSS on admission | 6(3–9) | 5(3–8) | 14(12–16) | < 0.001 |
| Male | 167(64.5) | 151(65.1) | 16(59.3) | 0.533 |
| Hypertension | 200(77.2) | 180(77.6) | 20(74.1) | 0.635 |
| Diabetes mellitus | 67(25.9) | 58(25) | 9(33.3) | 0.358 |
| Hyperlipidemia | 91(35.1) | 84(36.2) | 7(25.9) | 0.395 |
| Atrial fibrillation | 47(18.1) | 33(14.2) | 14(51.9) | < 0.001 |
| Hemorrhagic transformation | 24(9.3) | 12(5.2) | 12(44.4) | 0.009 |
| Symptom hemorrhagic transformation | 1(0.4) | 8(3.0) | ||
| Non -symptom hemorrhagic transformation | 11(4.4) | 4(1.5) | ||
| Stroke etiology (TOAST classification) | < 0.001 | |||
| Large artery atherosclerosis | 102(39.5) | 91(39.2) | 11(40.7) | |
| Cardioembolism | 58(22.4) | 34(14.7) | 14(51.9) | |
| Small vessel disease | 92(35.5) | 91(39.2) | 1(3.7) | |
| Other/unknown | 17(6.6) | 16(6.9) | 1(3.7) | |
| Infarct volume | < 0.001 | |||
| Large infarction | 28(10.8) | 10(4.4) | 18(66.7) | |
| Middle infarction | 119(45.9) | 111(47.8) | 8(29.6) | |
| Small infarction | 112(43.2) | 111(47.8) | 1(3.7) | |
| Plasma fibrinogen (g/L) | 3.9±1.3 | 3.8±1.4 | 4.3±1.3 | 0.156 |
| Creatinine (μM) | 72.7±30.5 | 76.7±27.3 | 72.3±31.0 | 0.476 |
| Blood uric acid (μM) | 294.1±107.9 | 296.4±106.9 | 274.4±109.3 | 0.314 |
| Glycosylated hemoglobin (%) | 6.7±1.6 | 6.7±1.9 | 6.7±1.8 | 0.65 |
| Drug treatment | ||||
| Antihypertensive agents | 194(74.9) | 176(75.8) | 18(66.7) | 0.112 |
| Antidiabetes drugs | 51(19.7) | 54(23.3) | 7(25.9) | 0.181 |
| Hypolipidemic Agents | 81(31.2) | 76(32.8) | 5(18.5) | 0.45 |
| Antithrombotic drugs | 252(97.3) | 227(97.8) | 25(92.6) | 0.158 |
Discrete variables are expressed as frequencies (percentages) and analyzed using the Fisher's exact test or chi-squared test. Continuous variables are expressed as the mean ± SD and analyzed using the two independent samples t-test. Non-normally distributed variables are reported as medians with interquartile ranges and analyzed using the Mann-Whitney U test. MRS: Modified Rankin Scale; NIHSS: National Institutes of Health Stroke Scale; TOAST: trial of ORG 10172 in acute stroke treatment.