Table 1.

Role of PINK1 expression in different cancers

Cancer	Effect in vitro	Effect in vivo	Reference
Bladder cancer	↓ Apoptosis	NT	Jin et al. (2012)
Breast cancer	↓ Apoptosis	NT	Berthier et al. (2011)
Breast cancer	↑ Cell proliferation	NT	O’Flanagan et al. (2015)
Cervical cancer	↑ Cell proliferation	NT	O’Flanagan et al. (2015)
Esophageal cancer	↑ Chemoresistance	↑ Chemoresistance	Yamashita et al. (2017)
Glioblastoma	↓ Cell proliferation	↓ Tumor growth	Agnihotri et al. (2016)
Hepatic cancer	↑ Cell proliferation	NT	Liu et al. (2017)
Hepatic cancer	↓ Apoptosis	NT	Yao et al. (2019)
Non-small cell lung cancer	↑ Cell proliferation ↓ Apoptosis	NT	Dai et al. (2019)
Non-small cell lung cancer	↑ Cell proliferation ↓ Apoptosis	↑ Tumor growth	Zhang et al. (2017)
Non-small cell lung cancer	↑ Cell proliferation ↓ Apoptosis	↑ Tumor growth	Liu et al. (2018)
Non-small cell lung cancer	NT	↑ Chemoresistance	Chang et al. (2018)
Pancreatic cancer	↑ Apoptosis	↓ Tumor growth	Li et al. (2018)

NT: Not tested; ↑: increase; ↓: decrease.