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. 2020 Oct 9;16(4):700–706. doi: 10.4103/1673-5374.295332

Figure 5.

Figure 5

Model for the accumulation of Nav channels in the axon initial segment.

The model contains 12 different species: CK2 (C1, C2, C3, C4), Nav (NaA, NaB, NaC, N1111), and AnkG (G1, G2, G3, G4); and sixteen rate constants. A total of eight reactions are used to model the phosphorylation (p) of Nav species through CK2 and the binding of phosphorylated Nav species to AnkG. AnkG: ankyrin-G; CK2: casein kinase 2; Nav: voltage-gated sodium channel.