Figure 2.

Schematic representation of the ATP synthase modifications involved in the progression of human diseases. Cardiovascular, Alzheimer’s, Amyotrophic Lateral Sclerosis (ALS), fragile X, Batten and Parkinson’s diseases are shown with different colors in the external perimeter. Changes in ATP synthase catalytic activity, assembly, subunit levels or subunit post-translational modifications and their consequence on mitochondrial morphology are listed inside the circle in correspondence of each related disease.