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WNT signaling pathways. WNT regulates at least three distinct intracellular signaling pathways: (a) The WNT/Planar Cell Polarity (PCP) pathway. (b,c) the WNT/β–catenin pathway: (b) the OFF state of the WNT/β–catenin pathway, absent WNTs stimulation; (c) the ON state of WNT/β–catenin pathway, when the WNT ligands couple to receptors. (d) the WNT/Ca2+ pathway. Please see text for other details.
