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. 2021 Apr 8;9(4):402. doi: 10.3390/biomedicines9040402

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The expression of FasL in TIICs does not correlate with disease severity. (A) The cohort of 41 SGC patients was stratified into 2 groups according to tumor grade (grade 0 and grade 1), and the Spearman correlation (r) according to the expression of FasL in TIICs in the tumor center was determined. The expression analyses were performed according to the scoring system described in the Materials and Methods section. The data are presented as a heat map with the scores, and the calculated p < 0.05 (red) was considered significant. (B) The patient cohort in (A) was stratified into 2 groups according to the absence (−) or presence (+) of lymph node (LN) metastases, and the Spearman correlation (r) was determined as in (A). (C) The patient cohort in (A) was stratified into 4 groups according to the primary tumor stage, and the Spearman correlation (r) was determined as in (A). (D–F) The cohort of 53 SGC patients was stratified into groups as in (A–C), and the Spearman correlation (r) according to the expression of FasL in TIICs in the tumor periphery was determined.