Table 4.
Alterations of neuronal GABAergic metabotropic receptors.
| Hippocampus | DG | Hilus | Sub | Amg | Temp ctx | TLE Model | Refs | |
|---|---|---|---|---|---|---|---|---|
| GABAB | ↓ | Human | [36] | |||||
| =(La) | Human | [47] | ||||||
| ↓ | Human | [125] | ||||||
| GABAB1 | ↓(BLA and CeM) | Human | [55] | |||||
| ↑ | Human | [119] | ||||||
| ↑(CA1) =(CA2–3) | ↑ | ↑ | = | Human | [122] | |||
| ↑(CA1) =(CA2–3) | ↑ | ↑ | Human | [123] | ||||
| ↓(CA1–2–3) | = | Rat KA | [124] | |||||
| ↓(CA1–3) | ↑ | ↓ | Mouse KA | [120] | ||||
| GABAB2 | ↓(BLA and CeM) | Human | [55] | |||||
| ↑ | Human | [119] | ||||||
| ↑(CA1–3) =(CA2) | ↑ | ↑ | = | Human | [122] | |||
| ↓(CA1–2–3) | = | Rat KA | [124] | |||||
| ↓(CA1–3) | ↑ | ↓ | Mouse KA | [120] |
Upregulation (↑), downregulation (↓), or no changes (=) of GABAergic metabotropic receptor expression in TLE (without TLE/mTLE specifications) compared to non-epileptic controls. Grey background highlights the metabotropic GABAB receptors main group. Amg: Amygdala; BLA: Basolateral amygdaloid nucleus; CeM: Central amygdaloid nucleus; DG: Dentate Gyrus; KA: Kainic acid; La: Lateral amygdaloid nuclei; Refs: References; Sub: Subiculum; Temp ctx: Temporal neocortex.