Table 5.
Alterations of gap junction subunits.
| Hippocampus | DG | Sub | Temp ctx | TLE Model | Refs | |
|---|---|---|---|---|---|---|
| Cx30 | = | Rat KA, Rat Kindling | [143] | |||
| Cx32 | ↑ | ↑ | Human | [139] | ||
| ↓ | = | ↓ | Human | [136] | ||
| = | Human | [138] | ||||
| = | Rat KA and Rat Kindling | [143] | ||||
| Cx36 | = | = | = | Human | [136] | |
| ↓(CA1–3) | ↓ | Mouse PILO | [159] | |||
| = | Rat PILO | [142] | ||||
| = | Rat Kindling | [141] | ||||
| = | Rat KA and Rat Kindling | [143] | ||||
| Cx40 | ↑(CA1–3) | ↑ | Mouse PILO | [140] | ||
| Cx43 | ↑ | ↑ | Human | [139] | ||
| ↑ | Human | [51] | ||||
| ↑ | ↑ | ↑ | Human | [136] | ||
| ↑(CA1–4) | Human | [137] | ||||
| ↑ | Human | [138] | ||||
| = | Rat PILO | [142] | ||||
| ↑(CA1–3) | ↑ | Mouse PILO | [140] | |||
| = | Rat Kindling | [141] | ||||
| = | Rat KA and Rat Kindling | [143] |
Upregulation (↑), downregulation (↓), or no changes (=) of gap junction subunit expression in TLE (without TLE/mTLE specifications) compared to non-epileptic controls. DG: Dentate Gyrus; KA: Kainic acid; PILO: Pilocarpine; Refs: References; Sub: Subiculum; Temp ctx: Temporal neocortex.