Figure 5.
Tumor volume (A) and survival ratio (B) versus time following administering 188Re-DXR-liposome (22.2 MBq of 188Re and 2 mg/kg DXR) (●), 188Re-liposome (22.2 MBq of 188Re) (∇), Lipo-Dox (2 mg/kg DXR) (■) and normal saline (♢) by triple intravenous injection on Day 0, 4 and 8 in C26 murine colon tumor-bearing mice. (C) MicroSPECT/CT image of 188Re-DXR-liposome at 120 day after treatment. (D) Statistics of therapeutic efficacy of 188Re-liposome compared with Lipo-DOX. CI: Combination Index; MGI: Mean Growth Inhibition. Figures adapted with permission from [34].