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. 2021 Apr 8;10(4):847. doi: 10.3390/cells10040847

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Desmoplastic stroma in Pancreatic Ductal Adenocarcinoma. The stroma makes up a large volume of PDAC tumours. Many cells found within the stroma can contribute to tumour progression and invasion, such as activated pancreatic stellate cells, inflammatory immune cells and cancer associated fibroblasts. The stroma is very stiff due to the high levels of Extracellular Matrix (ECM) proteins that are laid down by activated stellate cells and fibroblasts. PDAC tumours are hypoxic and do not contain many blood vessels [14]. Created with BioRender.com.