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. 2021 Apr 19;14:1389–1401. doi: 10.2147/IJGM.S310497

Table 2.

The Reported COVID-19 Vaccine Side Effects and Their Correlation with the Vaccine’s First, Second, and Both Doses

Frequency (n and %)
1st Dose (n = 237) 2nd Dose (n = 124) 1st & 2nd Doses (n=94) Chi-Square p value
Presence of Symptoms
Presence 202 (85.2%) 122 (98.4%) 68 (72.3%) < 0.0001***
Absence 35 (14.8%) 2 (1.6%) 26 (27.7%)
Local Symptoms 167 (70.5%) 100 (80.6%) 60 (63.8%) 0.0139*
Arm pain 4 (1.7%) 0 (0%) 0 (0%) 0.1563
Injection site pain 161 (67.9%) 100 (80.6%) 60 (63.8%) 0.0116*
Injection site swelling and redness 2 (0.8%) 0 (0%) 0 (0%) 0.3907
Hypersensitivity Symptoms 19 (8.0%) 18 (14.5%) 3 (3.2%) 0.0099**
A fast heartbeat 7 (3.0%) 11 (8.9%) 3 (3.2%) 0.0299*
Difficulty breathing 9 (3.8%) 5 (4.0%) 0 (0%) 0.1514
Bad rash all over the body 0 (0%) 1 (0.8%) 0 (0%) 0.2625
Severe body allergy 1 (0.4%) 0 (0%) 0 (0%) 0.6307
Burning sensation in the eye 2 (0.8%) 1 (0.8%) 0 (0%) 0.6743
Bone and Muscle Symptoms 9 (3.8%) 22 (17.7%) 7 (7.4%) < 0.0001***
Whole body pain 2 (0.8%) 8 (6.5%) 5 (5.3%) 0.0084**
Muscle pain 2 (0.8%) 1 (0.8%) 1 (1.1%) 0.9764
Muscle relaxation 0 (0%) 1 (0.8%) 0 (0%) 0.2625
Bone pain 3 (1.3%) 2 (1.6%) 0 (0%) 0.4949
Joint pain 0 (0.0%) 5 (4.0%) 1 (1.1%) 0.0060**
Back pain 2 (0.8%) 3 (2.4%) 0 (0%) 0.2044
Total Flu-Like Symptoms 77 (32.5%) 112 (90.3%) 29 (30.9%) < 0.0001***
Flu symptoms 26 (11.0%) 36 (29.0%) 7 (7.4%) < 0.0001***
Headache 43 (18.1%) 48 (38.7%) 17 (18.1%) < 0.0001***
Fever 3 (1.3%) 23 (18.5%) 4 (4.3%) < 0.0001***
Chills 2 (0.8%) 5 (4.0%) 1 (1.1%) 0.0772
Sore throat 2 (0.8%) 0 (0%) 0 (0%) 0.3907
Chest infection 1 (0.4%) 0 (0%) 0 (0%) 0.6307
Fatigue Symptoms 20 (8.4%) 25 (20.1%) 3 (3.2%) < 0.0001***
Tiredness 15 (6.3%) 19 (15.3%) 3 (3.2%) 0.2171
Dizziness and giddiness 4 (1.7%) 2 (1.6%) 0 (0%) 0.4523
Desire to sleep 1 (0.4%) 4 (3.2%) 0 (0%) 0.0273*
GIT Symptoms 14 (5.9%) 2 (1.6%) 1 (1.1%) 0.0383*
Nausea and vomiting 4 (1.7%) 1 (0.8%) 1 (1.1%) 0.7615
Gastroesophagitis 2 (0.8%) 0 (0%) 0 (0%) 0.3907
Diarrhea 7 (3.0%) 1 (0.8%) 0 (0%) 0.1169
Loss of appetite 1 (0.4%) 0 (0%) 0 (0%) 0.6307
Nerve Inflammation Symptoms 4 (1.7%) 0 (0%) 0 (0%) 0.1563
Bell’s palsy 3 (1.3%) 0 (0%) 0 (0%) 0.2493
Tingling 1 (0.4%) 0 (0%) 0 (0%) 0.6307
Miscellaneous Symptoms 1 (0.4%) 4 (3.2%) 0 (0%) 0.0273*
Lymph nodes tenderness and swelling 0 (0%) 2 (1.6%) 0 (0%) 0.0685
Elevated blood pressure 0 (0%) 1 (0.8%) 0 (0%) 0.2625
Blurred vision 0 (0%) 1 (0.8%) 0 (0%) 0.2625
Burning sensation when urinating 1 (0.4%) 0 (0%) 0 (0%) 0.6307

Notes: Results were offered as frequency (number (n) and percent (%)). Correlation between variables was evaluated using the Chi-square test. *Significant difference at p ≤ 0.05, **significant difference at p ≤ 0.01, and ***significant difference at p ≤ 0.001.