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. 2021 Apr 20;16:2949–2963. doi: 10.2147/IJN.S304515

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© 2021 Luo et al.

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Akk-EVs were tolerated in vivo and in vitro. (A and B) Average daily food (A) and water (B) consumption of mice were shown. n = 5 per group. (C) Representative H&E staining images of kidney and liver from subcutaneous RM-1 bearing mice treated with solvent or Akk-EVs for 13 days. Scale bar: 100 μm. n = 3 per group. (D) CCK-8 analysis of the viability of a panel of normal cell lines (RAW264.7, BPH-1, HMECs, and VSMC) receiving different doses of Akk-EVs for 24 h. n = 4 per group. Data are shown as mean ± SEM. NS, not significant.