Table 2.
Platelet reactivity presented as a median and 25%–75% interquartile range, IQR.
| Aggregation agonist | Aggregation in patients with thrombocytopenia | Aggregation in patients with thrombocythemia | Aggregation in controls | Statistical significance |
|---|---|---|---|---|
| (1) | (2) | (3) | ||
| AA whole group (n = 174) | 19 (7–28) | 80 (79–118) | 23 (15–38) | (2) vs. (1) p=0.001 (2) vs. (3) p=0.001 |
| AA on ASA only (n = 119) | 14 (5–29) | 80 (79–118) | 23 (17–38) | (2) vs. (1) p=0.004 (2) vs. (3) p=0.005 |
| AA on DAPT only (n = 55) | 19 (7–26) | 80 (70–110) | 20 (15–31) | (2) vs. (1) p=0.004 (2) vs. (3) p=0.005 |
| ADP whole group (n = 174) | 32 (16–44) | 124 (89–139) | 50 (32–71) | (2) vs. (1) p=0.005 (2) vs. (3) p=0.005 |
| ADP on ASA only (n = 119) | 36 (10–65) | 136 (89–139) | 52 (41–73) | (2) vs. (1) p=0.003 (2) vs. (3) p=0.004 |
| ADP on DAPT only (n = 55) | 30 (18–41) | 119 (114–124) | 36 (21–67) | (2) vs. (1) p=0.001 (2) vs. (3) p=0.001 |
| TRAP whole group (n = 174) | 41 (34–60) | 137 (120–180) | 90 (70–104) | (1) vs. (2) p=0.002 (2) vs. (3) p=0.002 (1) vs. (3) p=0.0002 |
| TRAP on ASA only (n = 119) | 36 (15–72) | 137 (125–180) | 86 (71–105) | (1) vs. (2) p=0.01 (2) vs. (3) p=0.01 (1) vs. (3) p=0.002 |
| TRAP on DAPT only (n = 55) | 42 (39–53) | 129 (104–139) | 93 (65–103) | (1) vs. (2) p=0.01 (2) vs. (3) p=0.01 (1) vs. (3) p=0.002 |
AU: arbitrary units, AA: arachidonic acid, ADP: adenosine diphosphate, TRAP: thrombin receptor-activating peptide, ASA–acetylsalicylic acid, DAPT: dual antiplatelet therapy, and IQR: 25%–75% interquartile range.