Table 2.
Nrf2, SOD2, GPX1, and GSTP1 genotypes in relation to the risk of ccRCC.
| Genotypes | ccRCC patients, n (%) | Controls, n (%) | OR (95% CI)a | p |
|---|---|---|---|---|
| Nrf2 (rs6721961) | ||||
| C/Cc | 166 (77) | 241 (72) | 1.00b | |
| C/A and A/Ad | 50 (23) | 95 (28) | 0.692 (0.370-1.295) | 0.250 |
| SOD2 (rs4880) | ||||
| Ala/Alae | 45 (30) | 111 (21) | 1.00b | |
| Ala/Val and Val/Valf | 175 (70) | 225 (79) | 4.521 (2.167-9.432) | <0.001 |
| GPX1 (rs1050450) | ||||
| Pro/Prog | 109 (49) | 142 (42) | 1.00b | |
| Pro/Leu and Leu/Leuh | 113 (51) | 194 (58) | 0.567 (0.323-0.994) | 0.048 |
| GSTP1 (rs1695) | ||||
| Ile/Ilei | 55 (25) | 159 (47) | 1.00b | |
| Ile/Val+Val/Valj | 168 (75) | 177 (53) | 3.714 (1.952-7.069) | <0.001 |
| GSTP1 (rs1138272) | ||||
| Ala/Alak | 197 (89) | 297 (89) | 1.00b | |
| Ala/Val+Val/Vall | 25 (11) | 39 (11) | 0.712 (0.309-1.642) | 0.426 |
| GSTP1 (rs1695 and rs1138272) | ||||
| (Ile/Ile) (Ala/Ala)m | 54 (24) | 144 (43) | 1.00b | |
| (Ile/Ile) (Ala/Val+Val/Val)n | 1 (1) | 15 (4) | 0.000 (NAq) | 0.999 |
| (Ile/Val+Val/Val) (Ala/Ala)o | 143 (64) | 153 (46) | 3.250 (1.668-6.331) | 0.001 |
| (Ile/Val+Val/Val) (Ala/Val+Val/Val)p | 24 (11) | 24 (7) | 2.719 (0.970-7.624) | 0.057 |
aOR: odds ratio adjusted for age, gender, BMI, pack-years, and hypertension; CI: confidence interval; breference group; cC/C: carriers of both referent alleles; dC/A and A/A: carriers of at least one variant allele; eAla/Ala: carriers of both referent alleles; fAla/Val and Val/Val: carriers of at least one variant allele; gPro/Pro: carriers of both referent alleles; hPro/Leu and Leu/Leu: carriers of at least one variant allele; iIle/Ile: carriers of both referent alleles; jIle/Val and Val/Val: carriers of at least one variant allele; kAla/Ala: carriers of both referent alleles; lAla/Val and Val/Val: carriers of at least one variant allele; m(Ile/Ile) (Ala/Ala): carriers of both referent alleles for rs1695 and rs1138272; n(Ile/Ile) (Ala/Val+Val/Val): carriers of both referent alleles for rs1695 and at least one variant allele rs1138272; o(Ile/Val+Val/Val) (Ala/Ala): carriers of at least one variant allele for rs1695 and both referent alleles for rs1138272; p(Ile/Val+Val/Val) (Ala/Val+Val/Val): carriers of at least one variant allele for both rs1695 and rs1138272; qNA: not applicable.