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. Author manuscript; available in PMC: 2021 Jun 21.
Published in final edited form as: Nat Hum Behav. 2020 Dec 21;5(4):482–496. doi: 10.1038/s41562-020-00980-y

Fig. 3. Cell-type transcriptomic profile enrichments underlying psychopathology and psychosocial factors.

Fig. 3.

Cross-data-set proportional significance (PS) and conditional independent (i.e., genetic signatures of cell-type pairs are distinguishable) of cell-type transcriptomic profile enrichments underlying unconditioned and conditioned GWAS for (A) risky behavior and (B) major depression. The human cell-type data sets from FUMA are labeled individually for each panel using different colors; cell types in the x and y directions are conditionally independent signals from within-data-set analysis performed in FUMA (cell-type enrichment step 228). Genetic signals from colinear cell types labeled with a single asterisk could not be differentiated from one another in FUMA.