Table 1. Causal inferences detected after multiple testing correction.
Significant causal relationships detected between psychopathology and psychosocial factors using latent causal variable analyses. For each significant causal estimate, all conditioned causal estimates between that phenotype pair are provided, highlighting at least nominally significant causal inferences after conditioning with education and socioeconomic status phenotypes that could not be detected in the original unconditioned trait pair.
| Trait 1 | Trait 2 | Conditioning | zscore | gcp.p | gcp.pm | gcp.pse | rho.est | rho.err | h2.zscore.1 | h2.zscore.2 | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Extraversion | Left Subcallosal Cortex | Original | 0.124 | 0.901 | −0.086 | 0.522 | −4.51E-05 | 0.038 | 7.772 | 12.423 | |
| Cognitive Performance | 3.626 | 4.57E-04 | −0.252 | 0.393 | 0.208 | 0.141 | 7.979 | 13.119 | |||
| Educational Attainment | 5.074 | 1.83E-06 | −0.165 | 0.378 | 0.201 | 0.141 | 7.742 | 13.207 | |||
| Highest Math Class | 8.599 | 1.23E-13 | −0.094 | 0.386 | 0.209 | 0.141 | 7.706 | 12.881 | |||
| Self-Rated Math Ability | 6.086 | 2.20E-08 | −0.304 | 0.326 | 0.19 | 0.13 | 6.92 | 11.845 | h2.zscore.1 too low | ||
| Left Subcallosal Cortex | Subjective Well-Being | Original | 0.336 | 0.737 | −0.004 | 0.434 | 0.036 | 0.029 | 6.894 | 20.441 | h2.zscore.1 too low |
| Cognitive Performance | 6.525 | 2.92E-09 | 0.746 | 0.168 | 0.28 | 0.091 | 7.365 | 25.776 | |||
| Educational Attainment | 6.227 | 1.16E-08 | 0.736 | 0.173 | 0.269 | 0.093 | 7.129 | 25.499 | |||
| Highest Math Class | 6.675 | 1.45E-09 | 0.753 | 0.164 | 0.265 | 0.09 | 7.04 | 25.116 | |||
| Self-Rated Math Ability | 7.699 | 1.05E-11 | 0.78 | 0.148 | 0.259 | 0.1 | 6.65 | 26.939 | h2.zscore.1 too low | ||
| Left Subcallosal Cortex | Alcohol Dependence | Original | 0.336 | 0.737 | −0.305 | 0.401 | −0.043 | 0.116 | 8.213 | 8.188 | |
| Cognitive Performance | 9.901 | 1.80E-16 | −0.293 | 0.254 | −0.146 | 0.202 | 7.244 | 8.203 | |||
| Educational Attainment | 1.256 | 0.212 | 0.042 | 0.164 | −0.099 | 0.216 | 6.467 | 8.001 | h2.zscore.1 too low | ||
| Highest Math Class | 1.008 | 0.316 | −0.005 | 0.21 | −0.087 | 0.214 | 6.484 | 8.148 | h2.zscore.1 too low | ||
| Self-Rated Math Ability | 3.422 | 9.05E-04 | −0.322 | 0.218 | −0.106 | 0.196 | 7.92 | 7.5 | |||
| Alcohol Dependence | Bipolar Disorder | Original | 0.093 | 0.926 | −0.023 | 0.56 | −0.001 | 0.022 | 7.986 | 35.945 | |
| Cognitive Performance | 6.884 | 5.37E-10 | 0.607 | 0.084 | 0.191 | 0.077 | 7.059 | 30.127 | |||
| Educational Attainment | 5.134 | 1.42E-06 | 0.843 | 0.252 | 0.282 | 0.084 | 6.346 | 30.211 | h2.zscore.1 too low | ||
| Highest Math Class | 6.201 | 1.30E-08 | 0.834 | 0.105 | 0.227 | 0.081 | 6.412 | 29.84 | h2.zscore.1 too low | ||
| Self-Rated Math Ability | 5.52 | 2.72E-07 | 0.197 | 0.051 | 0.187 | 0.073 | 8.028 | 27.169 | |||
| Income | 4.149 | 7.07E-05 | 0.563 | 0.168 | 0.262 | 0.08 | 6.556 | 31.5 | h2.zscore.1 too low | ||
| Deprivation Index | 0.789 | 0.431 | 0.433 | 0.333 | 0.207 | 0.078 | 5.75 | 32.739 | h2.zscore.1 too low | ||
| Bipolar Disorder | Major Depression | Original | 0.037 | 0.97 | 0.001 | 0.071 | 0.338 | 0.039 | 34.38 | 36.466 | |
| Cognitive Performance | 0.999 | 0.319 | 0.086 | 0.081 | 0.329 | 0.038 | 30.433 | 34.262 | |||
| Educational Attainment | 1.198 | 0.233 | 0.105 | 0.085 | 0.363 | 0.038 | 30.529 | 33.8 | |||
| Highest Math Class | 1.437 | 0.153 | 0.127 | 0.086 | 0.358 | 0.036 | 30.5 | 33.703 | |||
| Self-Rated Math Ability | 0.996 | 0.321 | 0.095 | 0.09 | 0.346 | 0.036 | 28.867 | 36.063 | |||
| Income | 1.777 | 0.078 | 0.139 | 0.078 | 0.362 | 0.036 | 31.788 | 34.07 | |||
| Deprivation Index | 4.844 | 4.71E-06 | 0.268 | 0.063 | 0.364 | 0.035 | 33.639 | 34.238 | |||
| Bipolar Disorder | Schizophrenia | Original | 0.182 | 0.856 | 0.024 | 0.133 | 0.711 | 0.026 | 32.985 | 34.422 | |
| Cognitive Performance | 0.649 | 0.518 | −0.121 | 0.173 | 0.701 | 0.023 | 30.263 | 40.071 | |||
| Educational Attainment | 0.619 | 0.537 | −0.107 | 0.164 | 0.697 | 0.023 | 30.312 | 39.843 | |||
| Highest Math Class | 0.755 | 0.452 | −0.138 | 0.175 | 0.707 | 0.023 | 29.911 | 40.022 | |||
| Self-Rated Math Ability | 0.757 | 0.451 | −0.133 | 0.17 | 0.704 | 0.024 | 28.396 | 36.96 | |||
| Income | 1.993 | 0.048 | 0.246 | 0.124 | 0.695 | 0.02 | 31.851 | 38.906 | |||
| Deprivation Index | 6.865 | 5.88E-10 | 0.68 | 0.11 | 0.674 | 0.021 | 33.358 | 40.103 | |||
| Bipolar Disorder | Volume of Right-Ventral Diencephalon | Original | 0.71 | 0.479 | 0.172 | 0.518 | −0.019 | 0.021 | 10.058 | 35.797 | |
| Income | 0.131 | 0.895 | 0.111 | 0.519 | 0.008 | 0.066 | 9.116 | 31.746 | |||
| Deprivation Index | 9.236 | 5.07E-15 | −0.673 | 0.171 | 0.184 | 0.04 | 28.882 | 33.264 | |||
| Left Insular Cortex | Depressive Symptoms | Original | 0.117 | 0.907 | 0.09 | 0.525 | −0.002 | 0.03 | 8.076 | 22.529 | |
| Cognitive Performance | 3.828 | 2.27E-04 | 0.683 | 0.204 | −0.283 | 0.093 | 7.767 | 23.319 | |||
| Educational Attainment | 2.828 | 0.005 | 0.612 | 0.241 | −0.264 | 0.095 | 7.547 | 22.23 | |||
| Highest Math Class | 4.04 | 1.06E-04 | 0.681 | 0.204 | −0.258 | 0.098 | 7.719 | 23.633 | |||
| Self-Rated Math Ability | 4.813 | 5.33E-06 | 0.736 | 0.175 | −0.281 | 0.104 | 8.284 | 23.571 | |||
| Obsessive Compulsive Disorder | Anorexia Nervosa | Original | 0.243 | 0.808 | 0.117 | 0.519 | −0.009 | 0.035 | 11.558 | 11.504 | |
| Cognitive Performance | 2.957 | 0.003 | −0.064 | 0.214 | 0.514 | 0.126 | 11.861 | 13.034 | |||
| Educational Attainment | 11.041 | 5.94E-19 | −0.805 | 0.375 | 0.479 | 0.135 | 10.921 | 12.701 | |||
| Highest Math Class | 4.252 | 4.81E-05 | 0.184 | 0.243 | 0.494 | 0.129 | 11.43 | 12.973 | |||
| Self-Rated Math Ability | 2.282 | 0.024 | −0.335 | 0.304 | 0.488 | 0.122 | 13.977 | 14.596 | |||
| Income | 6.585 | 2.20E-09 | −0.371 | 0.692 | 0.501 | 0.13 | 11.328 | 12.723 | |||
| Deprivation Index | 4.691 | 8.71E-06 | 0.144 | 0.46 | 0.495 | 0.129 | 11.647 | 12.78 | |||
| Openness | Autism Spectrum Disorder | Original | 0.274 | 0.784 | 0.097 | 0.544 | 0.315 | 0.111 | 14.625 | 8.038 | |
| Cognitive Performance | 6.147 | 1.67E-08 | 0.761 | 0.164 | 0.286 | 0.127 | 16.717 | 6.089 | h2.zscore.2 too low | ||
| Educational Attainment | 5.452 | 3.66E-07 | 0.741 | 0.174 | 0.26 | 0.138 | 16.176 | 4.898 | h2.zscore.2 too low | ||
| Highest Math Class | 5.865 | 5.96E-08 | 0.762 | 0.163 | 0.332 | 0.122 | 16.295 | 6.68 | h2.zscore.2 too low | ||
| Self-Rated Math Ability | 5.914 | 4.77E-08 | 0.777 | 0.157 | 0.351 | 0.116 | 15.955 | 7.782 | |||
| Income | 5.212 | 1.02E-06 | 0.742 | 0.174 | 0.343 | 0.122 | 16.291 | 6.466 | h2.zscore.2 too low | ||
| Deprivation Index | 5.219 | 9.93E-07 | 0.764 | 0.166 | 0.39 | 0.115 | 17.898 | 7.248 | |||
| Left Insular Cortex | Openness | Original | 0.498 | 0.619 | −0.225 | 0.314 | 0.041 | 0.057 | 7.151 | 8.094 | |
| Cognitive Performance | 5.967 | 3.77E-08 | 0.35 | 0.379 | 0.201 | 0.2 | 7.458 | 6.903 | h2.zscore.2 too low | ||
| Educational Attainment | 9.861 | 2.20E-16 | −0.092 | 0.381 | 0.187 | 0.221 | 7.311 | 5.574 | h2.zscore.2 too low | ||
| Highest Math Class | 8.221 | 8.04E-13 | 0.284 | 0.456 | 0.239 | 0.184 | 7.487 | 7.298 | |||
| Self-Rated Math Ability | 13.09 | 2.54E-23 | 0.252 | 0.384 | 0.198 | 0.17 | 7.583 | 7.598 | |||
| Right Insular Cortex | Volume of Right-Ventral Diencephalon | Original | 1.322 | 0.189 | 0.513 | 0.292 | −0.157 | 0.162 | 8.925 | 10.614 | |
| Income | 1.546 | 0.125 | 0.533 | 0.283 | −0.148 | 0.166 | 8.87 | 10.354 | |||
| Deprivation Index | 5.975 | 3.63E-08 | 0.478 | 0.178 | −0.131 | 0.096 | 8.735 | 30.666 | |||
| Volume of Right-Ventral Diencephalon | Openness | Original | 0.577 | 0.565 | −0.328 | 0.404 | −0.066 | 0.049 | 9.177 | 8.094 | |
| Income | 8.8 | 4.50E-14 | −0.203 | 0.442 | 0.27 | 0.096 | 28.449 | 8.041 | |||
| Deprivation Index | 0.042 | 0.966 | −0.061 | 0.302 | 0.153 | 0.17 | 9.327 | 7.409 |
Column Descriptions
zscore Z score for partial genetic causality
gcp p p; Significantly positive zscore implies trait 1 partially genetically causal for trait 2
gcp.pm posterior genetic causality proportion (positive = trait 1 > trait 2)
gcp.pse posterior standard error for genetic causality proportion
rho.est estimated genetic correlation
rho.err standard error for genetic correlation estimate
h2.zscore.1 z-score for trait 1 being significantly heritable
h2.zscore.2 z-score for trait 2 being significantly heritable