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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Transpl Infect Dis. 2020 Dec 7;23(2):e13514. doi: 10.1111/tid.13514

Figure 7. Macrophage and CD8+ T cell infiltration into the media/intima of allograft vessels is reduced in allografts derived from RCMV latently infected donors treated with clodronate.

Figure 7.

Immunohistochemical staining for the presence of macrophages and T cells of heart allografts harvested from Cohort #2 recipients at POD7, 14, 21, and 28 (n=5 per group/time point). Embedded tissue sections were cut and stained using antibodies directed against CD68 (macrophages; panels a and b) and CD8+ T cells (panels B and C). The frequency of each cell population was measured over 10 serial tissue slides and averaged to determine the mean number of cells that infiltrated into the vessel wall media and intima. Results for clodronate liposome treated animals are depicted in red and control liposome treated animals are shown in black for panels A and C. Images are representative stained sections from each time point (panels B and D). *p≤0.05 as determined by Student’s t-test.