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. Author manuscript; available in PMC: 2022 Apr 21.
Published in final edited form as: Neuron. 2021 Feb 22;109(8):1258–1273. doi: 10.1016/j.neuron.2021.02.003

Figure 1. Experience- and activity-induced changes to oligodendrocyte lineage cells and myelin.

Figure 1.

A) Enhanced or reduced experiential input or neuronal activity can directly alter any stage of oligodendrocyte lineage progression, including OPC (green) proliferation, OPC differentiation, or death of newly generated oligodendrocytes (blue). Experiential input or neuronal activity can also directly alter myelination by newly generated or preexisting oligodendrocytes by B) altering internodal localization, nodal geometry, or various aspects of myelin sheath geometry.