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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2021 Feb 6;154:60–69. doi: 10.1016/j.yjmcc.2021.01.005

Figure 3. Rad reduction increases SANcm ICa,L.

Figure 3.

A) Representative photomicrographs of SANcm selected for patching studies from CTRL (Ai) and cRadKO (Aii) hearts. B) Cell capacitance is not significantly different (p = 0.77). C) Family of ICa,L for CTRL (blue) and cRadKO (red). Scale bars: 5 pA/pF, 100 ms. D) Current-voltage relationships for peak ICa,L from CTRL and cRadKO SANcm. E) Maximal conductance is significantly increased (**p<0.01) and F) activation midpoint trends toward a negative shift with Rad deletion (p=0.2). N = 8 mice, n = 17 cells for CTRL; N = 9 mice, n = 21 cells for cRadKO.