A) Current-voltage relationships for peak ICa,L from CTRL (Ai) and cRadKO SANcm (Aii) for basal (closed symbols) and after 100 nM ISO (open symbols). B) Maximal conductance before and after ISO for CTRL (Bi, **p = 0.01) and cRadKO (Bii, p = 0.45). C) Activation midpoint before and after ISO for CTRL (Ci, *p = 0.05) and cRadKO (Cii, p = 0.68). N = 5 mice, n = 9 cells for CTRL; N = 4 mice, n = 9 cells for cRadKO.