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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2021 Feb 6;154:60–69. doi: 10.1016/j.yjmcc.2021.01.005

Figure 6. Rad deletion increases heart rate in the sleep phase.

Figure 6.

A) Representative ECG signals demonstrate an increase in heart rate during sleep after tamoxifen treatment, but no change while active. B) Continuous recording of heart rate over 48 hours, before tamoxifen (baseline) and after tamoxifen treatment (Post-TAM). C) Heart rate in the sleep phase increases after tamoxifen treatment in females (***p<10−3, N = 7 mice). D) No significant difference in heart rate during the active phase after tamoxifen treatment in females (p = 0.13). E) Heart rate in the sleep phase increases after tamoxifen treatment in males (**p = 0.003, N = 7 mice). F) Heart rate during the active phase increases after tamoxifen treatment in males (*p = 0.05).