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. Author manuscript; available in PMC: 2022 Apr 21.
Published in final edited form as: Neuron. 2021 Mar 1;109(8):1302–1313.e4. doi: 10.1016/j.neuron.2021.02.007

Figure 3. Ion binding profile in the selectivity filter of CNGA1.

Figure 3.

Shown are electron density maps of filter ions in the structures of the cGMP-bound open and apo closed CNGA1 in various salt conditions. All maps are scaled and contoured at 7 σ.

(A) Open CNGA1 in 150 mM KCl and 1 mM CaCl2.

(B) Closed CNGA1 in 150 mM KCl and 1 mM CaCl2.

(C) Open CNGA1 in 150 mM NaCl.

(D) Open CNGA1 in 150 mM NaCl and 1 mM CaCl2.

(E) Open CNGA1 E365Q mutant in 150 mM NaCl and 1 mM CaCl2.