Table 1.
WT | WT+HFD | sEH KO | sEH KO+HFD | |
---|---|---|---|---|
IVS d (mm) | 0.92±0.03 | 0.99±0.08 | 0.92±0.02 | 0.91±0.07 |
IVS s (mm) | 1.42±0.19 | 1.36±0.19 | 1.33±0.11 | 1.52±0.20 |
LVID d (mm) | 3.53±0.37 | 3.74±0.46 | 3.24±0.36 | 3.31±0.22* |
LVID s (mm) | 2.09±0.40 | 2.68±0.60* | 2.1±0.16 | 2.10±0.23* |
LVPW d (mm) | 0.99±0.069 | 1.1±0.047 | 0.95±0.12 | 0.99±0.08 |
LVPW s (mm) | 1.29±0.23 | 1.35±0.14 | 1.3±0.05 | 1.40±0.06 |
EF (%) | 55.36±7.31 | 57.16±12.22 | 57.1±2.34 | 67.72±6.28 |
FS (%) | 36.84±4.45 | 28.56±4.74* | 36.13±2.11 | 35.88±5.06** |
LV Mass(mg) | 97.27±5.049 | 121.8±8.76*** | 98.33±2.33 | 102.6±8.36** |
E/A | 1.43±0.05 | 1.21±0.05 | 1.41±0.02 | 1.39±0.10 |
WT+WFD vs. WT, sEH KO+HFD vs. WT+HFD,
p<0.05,
p<0.01,
p<0.005, n=3–5 per group.
IVS, interventricular septum; d, end-diastolic; s, systolic; LVID, left ventricular internal diameter; LVPW, left ventricular posterior wall thickness; EF, ejection fraction; FS, fractional shortening; LV, left ventricular; E/A, mitral doppler peak ratio.