This long-term safety analysis confirms the established safety profile of baricitinib 2 mg in atopic dermatitis.

There was no further increase in rates for adverse events, serious adverse events, or serious infections with long-term baricitinib 2-mg therapy as compared to rates with baricitinib 2 mg in the placebo-controlled period. Baricitinib 2 mg showed no increase in anemia, neutropenia, lymphopenia, or elevated liver enzymes compared to placebo.

There was an increase in cases of herpes simplex with baricitinib 2 mg compared with placebo, with lower rates for prolonged baricitinib 2 mg exposure. There was no increase in the risk of eczema herpeticum with baricitinib 2 mg.

A longer treatment duration is needed to appropriately assess the risk of malignancies and cardiovascular events.