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. Author manuscript; available in PMC: 2021 Sep 30.
Published in final edited form as: Nature. 2021 Mar 31;592(7855):639–643. doi: 10.1038/s41586-021-03378-6

Extended Data Fig. 9 |. Structural analysis MDB1 and various modes of RIFIN-receptor interaction.

Extended Data Fig. 9 |

a, Triangular architecture of LILRB1-containing MDB1 antibody Fab and structural comparison. Inside the ellipse it shown a schematic view of MDB1 with RIFIN attached to one arm of the Fab. The insets show structural superimposition of MDB1 domains to a non-inserted antibody and to apo LILRB1 (upper left: VH-VL region aligned with PDB 6P3B; upper right: CH-CL region aligned with PDB 6P3B; bottom right: LILRB1 insertion aligned with PDB 4LLA). b, Comparison of LILRB1/LAIR1 (grey) recognition by RIFIN PF3D7_1373400 (yellow) and RIFIN PF3D7_1040300 (PDB 7JZI, cyan), respectively. c, Comparison of LILRB1 (D1D2 in grey, D3D4 in red) recognition by RIFIN PF3D7_1254800 (PDB 6ZDX, green) and RIFIN PF3D7_1373400 (yellow).