Table 2.

Treatment-related adverse events

	Grades 1–3 (%)	Grades 4–5 (%)
Increase in alanine aminotransferase	8 (100)	2 (25)
Increase in aspartate aminotransferase	8 (100)	1 (12.5)
Increase in alkaline phosphatase	3 (37.5)	–
Blood bilirubin increased	1 (12.5)	–
Abdominal pain	3 (37.5)	–
Abdominal distension	1 (12.5)	–
Bloating	2 (25)	–
Diarrhea	1 (12.5)	–
Nausea	3 (37.5)	–
Vomiting	2 (25)	–
Pancreatitis	1 (12.5)	2 (25)
Edema limbs	6 (75)	–
Edema trunk	1 (12.5)	–
Hypertension	6 (75)	2 (25)
Dyspnea	3 (37.5)	2 (25)
Heart failure	0 (0)	1 (12.5)
Anemia	3 (37.5)	–
Decrease lymphocyte count	2 (25)	–
Decrease neutrophil count	2 (25)	–
Rash acneiform	1 (12.5)	–
Rash maculo-papular	4 (50)	–