Table 1.
Demographical and Clinical data in Late Elderly (LE) and Control Parkinson’s Disease subjects treated with Levodopa–Carbidopa Intrajejunal gel (LCIG) infusion
| LE-PD mean ± SD (range) |
Control-PD mean ± SD (range) |
p value | |
|---|---|---|---|
| Age (years) | 81.48 ± 1.73 (80–85) | 69.20 ± 5.45 (51–74) | < 0.0001* |
| Education (years) | 8.76 ± 4.05 (3–18) | 8.8 ± 4.57 (5–18) | 0.945 |
| Disease duration (years) | 21.28 ± 7.93 (10–51) | 21.28 ± 5.97 (13–38) | 0.409 |
| Weight (kg) | 61.56 ± 13.41 (33–95) | 65.48 ± 17.24 (40–120) | 0.409 |
| LCIG duration (months) | 59.28 ± 41.62 (4–133) | 60.08 ± 37.42 (6–146) | 0.846 |
| LCIG dose (ml/day) | 45.098 ± 13.15 (21–73.2) | 52.336 ± 18.96 (20.4–82.1) | 0.148 |
| Morning dose (ml) | 4.608 ± 2.72 (0–10.5) | 5.188 ± 2.69 (0–10.5) | 0.341 |
| UPDRS-II | 24.6 ± 9.18 (9–42) | 20.36 ± 8.91 (5–39) | 0.112 |
| UPDRS-III | 39.833 ± 13.61 (21–74) | 33.08 ± 14.28 (11–65) | 0.107 |
| UPDRS-IV | 6.8 ± 3.74 (1–14) | 8.92 ± 6.01 (4–34) | 0.157 |
| HY | 3.74 ± 0.98 (2–5) | 3.18 ± 0.97 (1.5–5) | 0.062 |
| RDRS | 6.04 ± 4.07 (0–12) | 9 ± 5.21 (0–18) | 0.047* |
| WOQ-19 total | 7.44 ± 5.01 (0–17) | 7.44 ± 4.22 (0–20) | 0.977 |
| WOQ-19 motor | 4.92 ± 3.05 (0–11) | 5.08 ± 2.41 (0–10) | 0.961 |
| WOQ-19 non-motor | 2.88 ± 3.55 (0–15) | 2.36 ± 2.50 (0–10) | 0.861 |
| NMSS | 78.72 ± 46.47 (19–201) | 81.64 ± 45.16 (17–188) | 0.749 |
| QUIP-RSa | 7.50 ± 3.62 (3–12) | 15.07 ± 10.08 (5–40) | 0.05* |
| FOG-Q | 14.083 ± 6.83 (3–26) | 13.84 ± 6.01 (3–24) | 0.936 |
| PDSS-2 | 9.924 ± 1.98 (4–39) | 18 ± 11.73 (2–49) | 0.594 |
| EDS | 5.8 ± 5.33 (0–20) | 6.48 ± 5.3 (0–19) | 0.449 |
| MOCA | 17.52 ± 7.2 (2–28) | 20.84 ± 6.58 (2–29) | 0.060 |
FOG-Q freezing of gait questionnaire, EDS Epworth Sleepiness scale, HY Hoehn–Yahr stage, L Levodopa–Carbidopa intestinal gel infusion, MOCA Montreal Cognitive Assessment, NMSS Non-Motor Symptoms Scale, PDSS-2 Parkinson’s Disease Sleep scale-II, QUIP-RS Questionnaire for Impulsive–Compulsive Disorders in Parkinson’s Disease–Rating Scale, RDRS Rush Dyskinesia rating scale, UPDRS Unified Parkinson’s Disease Rating Scale, WOQ-19 Wearing Off Questionnaire 19 items
aQUIP-RS calculated on LE-PD (n = 6) and Control-PD (n = 14) with impulsive–compulsive behavior
*Significant values are bolded