Table 1.

Every disease has an inflammatory component associated with malfunctioning mitochondria and increased secretion of lactic acid resulting from metabolic rewiring.

Organ	Disease	Inflammation	Mitochondrial Impairment	Lactic Acid Concentration
Brain	Autism	Yes	Yes [58]	Increased [59]
	Schizophrenia	Yes	Yes [58]	Increased [60]
	Meningitis	Yes	Yes [61]	Increased [60]
	Encephalitis	Yes	Yes [62]	Increased [63]
	Alzheimer	Yes	Yes [27]	Increased [27]
	Parkinson	Yes	Yes [64]	Stable under treatment [65]
	Huntington	Yes	Yes [66]	Increased [67]
Cardio-vascular	Cardiac infract	Yes: scarring	Yes [68]	Increased [69]
	Cardiac failure	Yes	Yes [70]	Increased [69]
	Stroke	Yes: scarring	Yes [71]	Increased [72]
Bronchia alveolar	Infection	Yes	Yes [73]	Not available
	Fibrosis	Yes	Yes [74]	Increased [75]
	Emphysema	Yes	Yes [76]	Increased [77]
	Cancer	Yes	Yes [27]	Increased [27]
Joint and muscular	Arthritis	Yes	Yes [78]	Increased [77]
	Myositis	Yes	Yes [79]	Not available
	Sarcoma	Yes	Yes [27]	Increased [27]
GI tract	Hepatitis	Yes	Yes [80]	Increased [80]
	Cirrhosis	Yes	Yes [81]	Increased [82]
	ulcerative colitis	Yes	Yes [83]	Increased [84]
Urinary tract	Cystitis	Yes	Yes [85]	Increased [86]
	Cancer	Yes	Yes [27]	Increased [27]
Autoimmune disease	Scleroderma	Yes	Yes [87]	Not available
	Lupus	Yes	Yes [88]	Increased [89]
	Sarcoidosis	Yes	Yes [90]	Increased [91]
Down’ syndrome	Diffuse	Yes	Yes [92]	Increased [93]
Cystic fibrosis	Lung and GI tract	Yes	Yes [94]	Increased [95]
Aging	Diffuse	Yes	Yes [27]	Increased [27]