Table 1.
List of potential lipid biomarkers for the differentiation of antimony resistant phenotypes in Leishmania.
| ID | Lipid Ion | Polarity | RT | CalcMz | FC | p-Value | Category | Main Class | Comparison |
|---|---|---|---|---|---|---|---|---|---|
| 3127 | SPH(d19:0) | Positive | 9.606341 | 316.321 | −74.921 | 3.97 × 10−3 | SL | PSL | Basal changes in resistant strain |
| 3050 | PE(18:0p/22:6) | Positive | 17.03432 | 776.5589 | −38.519 | 8.37 × 10−4 | GP | GPE | Basal changes in resistant strain |
| 2673 | DG(18:0/14:0) | Positive | 17.03642 | 586.5405 | −32.643 | 1.36 × 10−3 | GL | DRG | Basal changes in resistant strain |
| 2708 | DG(18:1/18:2) | Positive | 16.97843 | 619.5296 | −20.236 | 2.46 × 10−3 | GL | DRG | Basal changes in resistant strain |
| 2929 | PC(40:8) | Positive | 15.28111 | 830.5694 | 16.74 | 6.18 × 10−3 | GP | GPC | Basal changes in resistant strain |
| 2832 | PC(30:1) | Positive | 14.87514 | 726.5044 | 16.644 | 2.16 × 10−3 | GP | GPC | Basal changes in resistant strain |
| 2777 | LPC(18:3) | Positive | 10.05254 | 518.3241 | 13.912 | 1.99 × 10−4 | GP | GPC | Basal changes in resistant strain |
| 2880 | PC(36:4) | Positive | 15.87022 | 782.5694 | 7.685 | 9.10 × 10−5 | GP | GPC | Basal changes in resistant strain |
| 1201 | PC(16:1/18:3) | Positive | 14.89068 | 798.5291 | −8.056 | 4.68 × 10−4 | GP | GPC | Resistant strain growing under SbIII |
| 1225 | PC(18:3/18:2) | Negative | 15.12758 | 764.5236 | −8.372 | 4.98 × 10−3 | GP | GPC | Resistant strain growing under SbIII |
| 1619 | PC(15:0/18:2) | Positive | 15.43099 | 744.5538 | −5.797 | 5.07 × 10−3 | GP | GPC | Resistant strain growing under SbIII |
| 1182 | PC(18:3/13:0) | Positive | 14.22137 | 758.4978 | −4.878 | 1.86 × 10−3 | GP | GPC | Resistant strain growing under SbIII |
| 1491 | DG(18:1/18:2) | Positive | 16.97117 | 641.5115 | 18.504 | 1.37 × 10−3 | GL | DRG | Resistant strain growing under SbIII |
| 1940 | SPH(d20:0) | Positive | 10.43559 | 330.3367 | 11.92 | 6.18 × 10−4 | SL | PSL | Resistant strain growing under SbIII |
| 1853 | PE(18:3e/19:1) | Positive | 16.97688 | 762.5408 | 10.462 | 8.59 × 10−4 | GP | GPE | Resistant strain growing under SbIII |
| 1498 | DG(18:4/18:1) | Positive | 16.20263 | 637.4802 | 5.548 | 1.08 × 10−3 | GL | DRG | Resistant strain growing under SbIII |
| 10 | LPC (15:0) | Positive | 8.611845 | 526.315 | −6.48 | 9.36 × 10−5 | GP | GPC | Sensitive strain growing under SbIII |
| 568 | PE(19:0/18:2) | Positive | 16.90759 | 758.5694 | −7.406 | 8.40 × 10−3 | GP | GPE | Sensitive strain growing under SbIII |
| 172 | PE(18:0/22:6) | Negative | 16.58543 | 790.5392 | −5.265 | 4.00 × 10−4 | GP | GPE | Sensitive strain growing under SbIII |
| 752 | TG(18:0/13:0/18:1) | Positive | 20.97317 | 841.7256 | −5.992 | 8.90 × 10−3 | GL | TRG | Sensitive strain growing under SbIII |
| 868 | TG(18:3/14:3/22:6) | Positive | 19.10632 | 884.6763 | 11.242 | 2.26 × 10−6 | GL | TRG | Sensitive strain growing under SbIII |
| 867 | TG(18:1/14:4/22:6) | Positive | 19.3979 | 891.6473 | 12.049 | 8.53 × 10−6 | GL | TRG | Sensitive strain growing under SbIII |
| 720 | TG(14:0/14:4/18:3) | Positive | 18.52557 | 782.6293 | 8.3318 | 3.77 × 10−5 | GL | TRG | Sensitive strain growing under SbIII |
| 1034 | TG(18:3/20:3/22:6) | Positive | 20.30457 | 968.7702 | 10.236 | 2.01 × 10−4 | GL | TRG | Sensitive strain growing under SbIII |
ID, random identification number assigned per lipid ion; RT, retention time; CalcMz, calculated mass; FC, fold change; Category, Lipid Maps category; Main class, Lipid Maps main class; GP, Glycerophospholipids; GL, Glycerolipids; SL, Sphingolipids; GPC, Glycerophosphocholines; GPE, Glycerophosphoethanolamines; TRG, Triradylglycerols; DRG, Diradylglycerols; PSL, Phosphosphingolipids.