Table 8.
Fitting parameters of different kinetic models for the diclofenac sodium release amounts at pH = 7.4.
| Zero Order |
First Order | Korsmeyer– Peppas |
Higuchi | Hixson– Crowell |
||
|---|---|---|---|---|---|---|
| Sample | Temperature (°C) |
k0 (mol.dm−3·h−1) r2 |
k1(h−1) r2 |
kKP(h−n) n r2 |
kH(h−0.5) r2 |
kHC(h−1/3) r2 |
| SBA-15(C) | 37 | 12.126 0.7064 |
0.6909 0.4863 |
* | 21.594 0.9603 |
0.3442 0.8632 |
| 42 | 12.437 0.5548 |
0.3732 0.7581 |
* | 37.046 0.8144 |
0.3827 0.6893 |
|
| SBA-15(C)-800 | 37 | 1.5813 0.5341 |
0.0239 0.6172 |
0.0003 2.7 0.9364 |
10.055 0.8262 |
0.0322 0.5897 |
| 42 | 8.4882 0.6977 |
0.1747 0.8097 |
0.0025 1.7 0.8073 |
27.842 0.9064 |
0.2813 0.8217 |
|
| SBA-15(C)-1300 | 37 | 1.6105 0.4397 |
0.0179 0.4459 |
0.0001 3.4 0.9544 |
8.7135 0.6318 |
0.0316 0.4696 |
| 42 | 9.3551 0.8143 |
0.0490 0.4558 |
0.0118 1.4 0.8398 |
29.258 0.9618 |
0.0583 0.4352 |
|
| SBA-15(C)-2000 | 37 | 1.7957 0.5268 |
0.0216 0.5467 |
0.0009 2.3 0.9932 |
11.4221 0.8156 |
0.0355 0.5604 |
| 42 | 2.5615 0.6401 |
0.1027 0.9345 |
0.0043 1.8 0.8773 |
13.708 0.8788 |
0.0609 0.7425 |
|
| Diclofenac Duo | 37 | 18.435 0.8911 |
0.4511 0.9261 |
* | 46.3081 0.9301 |
0.5726 0.9699 |
| 42 | 3.0354 0.3521 |
0.1713 0.6017 |
* | 21.2451 0.6599 |
0.6291 0.9502 |
* Because of the rapid drug release in the first hours, Korsmeyer–Peppas model could not be applied.