Table 2.
Terrestrial plant-derived anticancer cyclopeptides.
| Name | Biological Source | Anticancer Activity | Reference |
|---|---|---|---|
| Cherimolacyclopeptides C-F (73–76) | Seeds of Annona cherimola | Cytotoxicity against KB cell. (IC50 = 0.017 to 0.97 µM) | [123,124,125] |
| Integerrimide C (77) | Latex of Jatropha integerrima | Cytotoxicity against KB (IC50 = 1.7 µM) cell. | [126] |
| LOB3 (78) | Flaxseed oil | Cytotoxicty against A375, SKBR3 and MCF7 cells. | [128,129] |
| Cambodine A (79) | Root bark of Ziziphus cambodiana | Cytotoxicity against BC-1 (IC50 = 11.1 µM) cell. | [130] |
| Longicalycinin A (80) | Dianthus superbus | Growth inhibitory activity against HepG2 (IC50 = 22.13 μM) cell. | [131,132,133] |
| Dianthin E (81) | Dianthus superbus | Cytotoxicity against HepG2 (IC50 = 3.51 μM) cell. | [134] |
| [1-8-NαC]-Zanriorb A1 (82) | Leaves of Zanthoxylum riedelianum | Cytotoxicity against Jurkat leukemia T cell (IC50 = 218 nM). | [136] |
| Justicianenes B-D (83–85) | Justicia procumbens L. | Justicianene D displayed cytotoxicity against MCF-7 cells (IC50 = 90 μM). | [137] |
| GCP-1 (86) | Ginseng | Cytotoxicity against SGC-7901 cells (IC50 = 37.8 μM). | [138] |
| Rubipodanin A (87) | Roots and rhizomes of Rubia podantha | Cytotoxicity against HeLa, A549 and SGC-7901 cells. (IC50 = 3.80 to 7.22 μM) | [143] |
| Rubipodanin B (88) | Rubia podantha | Cytotoxicity against MDA-MB-231 (IC50 = 1.47 μM), SW620 (IC50 = 0.69 μM) and HepG2 (IC50 = 3.37 μM) cells. | [144] |
| RA-XII (89) | Rubia yunnanensis | Inhibitory effects on 4T1 ((IC50 = 606 nM and 96 nM for 24 and 48 h, respectively), SW260 and HT29 cells. | [145,146,147] |
| RA-XXV (90) | Roots of Rubia cordifolia L. | Cytotoxicity against HL-60 ((IC50 = 62 nM) and HCT116 cells ((IC50 = 28 nM). | [149] |
| RA-XXVI (91) | Roots of Rubia cordifolia L. | Cytotoxicity against HL-60 ((IC50 = 66 nM) and HCT116 cells ((IC50 = 51 nM). | [149] |
| HB7 (92) | Hedyotis biflora | Cytotoxicity against BxPC3 (IC50 = 0.68 μM), Capan2 (IC50 = 0.45 μM), MOH-1 (IC50 = 0.33 μM) and PANC1 (IC50 = 0.36 μM) cells. | [150] |
| Cliotides T1-T4 (93–96), cliotide T7 (97), cliotide T10 (98), cliotide T12 (99) | Clitoria ternatea | Cliotides T1-T4: cytotoxicity against HeLa (IC50 = 0.6 to 8.0 μM) cell. Cliotides T2, T4, T7, T10 and T12: cytotoxicity against A549 (IC50 = 0.21 to 7.59 μM) and A549/paclitaxel (IC50 = 0.45 to 7.92 μM) cells. |
[151,152] |
| psyle E (100) | Psychotria leptothyrsa var. longicarpa | Cytotoxicity against U937-GTB IC50 = 0.76 μM) cell. | [153] |
| Vigno 5 (101) | Viola ignobilis | Pro-apoptotic activity on HeLa cell. | [154,155] |
| Cycloviolacin O2 (CyO2) (102) | Viola odorata L. | Cytotoxicity against U937 GTB (IC50 = 0.75 μM), CCRF-CEM, NCI-H69 and HT29 cells. | [156,157,158,159,160] |
| Viphi A-G (103–109) | Viola philippica | Cytotoxicity against MM96L, HeLa, BGC-823, HFF-1 cells, but viphi D and E showed no activity against BGC-823 cell. (IC50 = 1.03 to 7.92 μM) | [161] |
| Vaby A (110) and D (111) | Viola abyssinica | Cytotoxicity against U-937 (IC50 = 2.6 and 7.6 μM, respectively) cell. | [162] |
| Vibi G (112) and H (113) | Viola biflora | Cytotoxicity against U-937 GTB (IC50 = 0.96 and 1.6 μM, respectively) cell. | [163] |
| Vitri A (114) | Viola tricolor | Cytotoxicity against U-937 GTB (IC50 = 0.6 µM) and RPMI-8226/s (IC50 = 1 µM) cells. Cytotoxicity against U251, MDA-MB-231, A549, DU145 and BEL7402 cells (IC50 = 3.07 to 6.03 μM). |
[164,165] |
| Varv A (115) and E (116) | Viola tricolor | Cytotoxicity against U-937 GTB (IC50 = 6 and 4 µM, respectively) and RPMI-8226/s (IC50 = 3 and 4 µM, respectively) cells. | [164] |
| Vitri F (117) | Viola tricolor | Cytotoxicity against U251, MDA-MB-231, A549, DU145 and BEL7402 cel ls (IC50 = 2.74 to 6.31 μM). | [165] |