Table 4.
Fungi-derived anticancer cyclopeptides.
| Name | Biological Source | Anticancer Activity | Reference |
|---|---|---|---|
| Anticancer Cyclopeptides Derived from Non-Marine Fungi | |||
| 1-alaninechlamydocin (205) | Tolypocladium sp. | Cytotoxicity against MIA PaCa-2 (GI50 = 5.3 nM, LC50 = 22 nM) cell. | [296] |
| Pseudoxylallemycin C (206) | Pseudoxylaria sp. X802 | Anti-proliferative effect to K562 (GI50 = 6.8 µM) cell. Cytotoxicity against HeLa (CC50 = 16.68 µM) cell. | [297] |
| Cycloaspeptides F (207) and G (208) | Isaria farinosa | Inhibitory activities toward MCF7 (GI50 = 18.7 and 15.2 µM, respectively) cell. | [298] |
| Malformin A1 (MA1) (209) | Aspergillus niger | Cytotoxicity against PC3 (IC50 = 130 nM), LNCaP (IC50 = 90 nM), HeLa (IC50 = 9.48 nM) and P388 (IC50 = 132.9 nM) cells. | [299,300,301] |
| Malformin E (210) | Aspergillus tamarii | Cytotoxicity against MCF7 (IC50 = 0.65 µM) and A549 (IC50 = 2.42 µM) cells. | [302] |
| Neo-N-methylsansalvamide (211) | Fusarium solani KCCM90040 | Cytotoxicity against A549, SK-OV-3, SK-MEL-2 and MES-SA cells. (EC50 = 10.0 to 14.74 µM) Synergistic effect of neo-N-methylsansalvamide and paclitaxel when acting against MES-SA, HCT15, MES-SA/DX5 and HCT15/CL05 cells. |
[303,304] |
| Cylindrocyclin A (212) | Cyclindrocarpon sp. strain A101-96 | Cytotoxicity against COLO-320, HL-60, L1210 and human T lymphocyte Jurkat cells. (IC50~11 µM) | [305] |
| Gymnopeptides A (213) and B (214) | Mushroom, Gymnopus fusipes | Anti-proliferative activities against HeLa, A431, T47D, MCF7 and MDA-MB-231 cells. (IC50 = 18.0 to 88.4 nM and 14.0 to 44.3 nM, respectively) | [306,307] |
| Phomopsin F (215) | Diaporthe toxica | Impact on viability and vitability of HepG2 (IC50 = 6.1 µM) cell. | [308] |
| Pteratides I-IV (216–219) | Pterula sp. | Cytotoxicity against P388 (IC50 = 41 nM, 40 nM, 7.4 µM and 2.9 µM, respectively) cell. | [309] |
| Anticancer Cyclopeptides Derived from Marine Fungi | |||
| Asperterrestide A (220) | Aspergillus terreus SCSGAF0162 | Cytotoxicity against U937 (IC50 = 6.4 μM) and MOL-4 (IC50 = 6.2 μM) cells. | [310,311] |
| Cordyheptapeptide A (221) | Cordyceps sp. BCC 1788 | Anti-proliferative activities to KB (IC50 = 0.78 μM), BC (IC50 = 0.2 μM), NCI-H187 (IC50 = 0.18 μM) and Vero (IC50 = 14 μM) cells. | [312,313] |
| Cordyheptapeptide B (222) | Cordyceps sp. BCC 16173 | Anti-proliferative activities to KB (IC50 = 2.0 μM), BC (IC50 = 0.66 μM), NCI-H187 (IC50 = 3.1 μM) and Vero (IC50 = 1.6 μM) cells. | [312,313] |
| Cordyheptapeptide C (223) | Acremonium persicinum | Cytotoxicity against SF-268 (IC50 = 3.7 μM) and MCF7 (IC50 = 3.0 μM) cells. | [314] |
| Cordyheptapeptide E (224) | Acremonium persicinum | Cytotoxicity against SF-268 (IC50 = 3.2 μM), MCF7 (IC50 = 2.7 μM) and NCI-H460 (IC50 = 4.5 μM) cells. | [314] |
| Scytalidamides A (225) and B (226) | Scytalidium sp. | Cytotoxicity against HCT116 (IC50 = 2.7 and 11.0 µM, respectively) cell. Moderate cytotoxicitty in NCI 60 cell line panel. (Mean GI50 = 7.9 and 4.1 µM, respectively) |
[315] |
| Zygosporamide (227) | Zygosporium masonii | Cytotoxicity against SF-268 (IC50 = 6.5 nM) and RXF393 (IC50 ≤ 5.0 nM) cells. | [316,317] |
| Sansalvamide A (228) | Fusarium sp. | Cytotoxicity against HCT116, COLO 205 and SK-MEL-2 (IC50 = 9.7, 3.46 and 5.84 μM, respectively) cells. | [318,319,320,321,322,323] |
| Clavatustide A (229) | Aspergillus clavatus | Anti-proliferative activity against Hep G2, SMMC-7721 and Bel-7402 cells. (IC50~32 μM) | [324] |
| Clavatustide B (230) | Aspergillus clavatus | Anti-proliferative activity against Hep G2, SMMC-7721 and Bel-7402 cells. (IC50~32 μM) Cell growth inhibitory activity against PANC-1 and PC3 cells. |
[324,325] |
| Sclerotiotide M (231) | Aspergillus ochraceopetaliformis DSW-2 | Cytotoxicity against HPAC and BXPC3 cells. (IC50 > 20 μM) | [326] |
| Scopularides A (232) and B (233) | Scopulariopsis brevicaulis | Viability inhibition of several cancer cell lines including Colo357, Panc89 and HT29 cells at a concentration of 14.87 μM. | [327] |
| IB-01212 (234) | Clonostachys sp. ESNA-A009 | Inhibitory activity against several cancer cell lines including LNCaP, SKBR3, HT29 and HeLa with the GI50 values on the order of 10−8 M. | [328,329,330,331] |
| Microsporins A (235) and B (236) | Microsporum cf. gypseum | Cytotoxicity especially against HCT116 cell. (IC50 = 1.12 and 15.82 μM, respectively) | [332,333,334] |