Table 1.
The features contained in each bicluster, with non-annotated bacterial genera excluded. Positive log2 fold change indicates higher abundance in the HFD group.
| Bicluster | Genera in Bicluster | Log2 Fold Change HFD/HFD + XOS | Log2 Fold Change HFD/LFD | Metabolites in Bicluster | Log2 Fold Change HFD/HFD + XOS | Log2 Fold Change HFD/LFD |
|---|---|---|---|---|---|---|
| SCFA Bicluster | [Ruminococcus] gauvreauii group | –0.14 | –2.43 * | 1,3-dihydroxyacetone | 0.17 | –0.61 |
| Anaerostipes | –1.41 | –4.04 ** | 2-oxoglutarate | 0.27 | –0.44 | |
| Christensenellaceae R-7 group | 0.42 | –0.2 | Acetate | –0.05 | –0.52 ** | |
| Clostridium sensu stricto 1 | –0.23 | –3.78 * | Butyrate | –0.07 | –1.51 ** | |
| Faecalibaculum | 1.48 | –5.69 ** | Glucose | 0.11 | –1.96 ** | |
| GCA-900066225 | –0.81 | –2.47 ** | Methionine | 0.38 | –0.06 | |
| Papillibacter | 0.86 | –3.87 ** | Nicotinate | 0.05 | –1.06 ** | |
| Parabacteroides | 0.29 | –0.48 * | Propionate | –0.01 | –0.62 ** | |
| Rodentibacter | –0.83 | –2 | Pyruvate | 0.63 | –0.98 * | |
| Romboutsia | 1.69 | –0.75 | Uracil | 0.59 | –0.51 * | |
| Ruminiclostridium 5 | 1.39 * | –2.31 ** | Urocanate | 0.48 | –0.63 | |
| Ruminococcaceae UCG-014 | 0.25 | –0.82 | ||||
| Turicibacter | 1.16 | –3.96 ** | ||||
| Product Bicluster | [Bacteroides] pectinophilus group | –3.51 | 0.8 | Aspartate | 0.06 | 0.17 |
| [Eubacterium] coprostanoligenes group | –0.42 | –0.12 | Isobutyrate | 0.08 | 0.57 | |
| [Eubacterium] xylanophilum group | 0.81 | 0.66 | Threonine | 0.09 | 0.47 * | |
| Akkermansia | –0.29 | 0.21 | Valerate | 0.25 | 0.47 * | |
| Alistipes | –0.01 | 1.13 * | ||||
| Defluviitaleaceae UCG-011 | 0.37 | 2.38 ** | ||||
| Family XIII AD3011 group | 1.13 ** | 1.33 * | ||||
| Odoribacter | –0.33 | 1.35 | ||||
| Ruminococcaceae UCG-005 | 0.77 | 1.93 | ||||
| TMA Bicluster | Allobaculum | 0.93 | 1.6 | Choline | 0.97 | 1.45 * |
| Alloprevotella | –0.5 | –0.05 | Ethanol | –0.2 | –0.08 | |
| Bacteroides | –0.1 | 0.38 | Fumarate | 0.01 | –0.39 | |
| Blautia | –0.25 | –0.69 | Glycine | –0.81 * | 0.48 | |
| Erysipelatoclostridium | –1.31 | –0.04 | Methanol | –1.09 | 0.24 | |
| Escherichia-Shigella | –1.82 ** | –0.93 | Trimethylamine | 0.15 | 0.11 | |
| Faecalitalea | –0.65 | 1.24 * | ||||
| Flavonifractor | 0.96 | 3.07 * | ||||
| Fusicatenibacter | 3.88 | 10.07 | ||||
| Holdemania | –0.32 | 0.9 | ||||
| Intestinimonas | –0.18 | –0.57 | ||||
| Lachnospiraceae UCG-008 | –0.82 | 1.46 | ||||
| Marvinbryantia | –1.65 ** | –0.95 | ||||
| Oscillospira | –0.83 | 8.89 | ||||
| Parasutterella | 0.63 | 0.98 | ||||
| AA Bicluster | Bilophila | 0.61 * | 3.41 ** | Alanine | 0.19 | 0.04 |
| Desulfovibrio | 0.75 | –0.25 | Formate | –0.8 | –0.75 ** | |
| Eisenbergiella | –0.03 | 0.05 | Glutamate | 0.08 | –0.03 | |
| Erysipelotrichaceae UCG-003 | –0.23 | –1.25 | Hypoxanthine | 1.8 ** | –0.46 * | |
| Lachnospiraceae NK4A136 group | 1.27 | 0.87 | Isoleucine | 0.34 * | –0.16 | |
| Mucispirillum | 1.51 | 1.03 | Leucine | 0.31 | 0.07 | |
| Oscillibacter | 0.7 * | –0.97 * | Methylamine | 0.73 ** | 0.5 | |
| Roseburia | –0.08 | –1.42 | Phenylalanine | 0.45 * | –0.04 | |
| Ruminiclostridium | 1.27 | –0.06 | Proline | 0.33 | 0 | |
| Ruminiclostridium 9 | 0.55 | 0.31 | Tyrosine | 0.55 ** | 0.02 | |
| Ruminococcaceae UCG-003 | 0.67 | 0.18 | ||||
| Ruminococcaceae UCG-004 | –2.8 | –2.33 | ||||
| Ruminococcus 1 | 0.13 | 0.35 | ||||
| Isovalerate Bicluster | [Eubacterium] nodatum group | 0.36 | 3.31 ** | Glycerol | 1.57 | 3.0 ** |
| Candidatus Soleaferrea | 0.58 | 2.21 ** | Isovalerate | 0.37 * | 1.02 ** | |
| GCA-900066575 | 0.41 | 1.0 * | Lactate | 0.63 | 0.9 | |
| Lachnoclostridium | –0.33 | 2.38 * | Malonate | –0.11 | 0.28 | |
| Lactobacillus | 0.28 | 0.51 | Succinate | –0.35 | –1.53 | |
| Lactococcus | 0.54 | 0.6 | Tryptophan | –0.11 | 0.45 | |
| Rikenellaceae RC9 gut group | 0.31 | 1.43 * | Valine | 0.39 * | 0.09 | |
| Ruminococcaceae NK4A214 group | –0.04 | 1.91 ** | ||||
| Sellimonas | 0.57 | 2.57 ** | ||||
| UBA1819 | –0.63 | 1.86 ** |
Mann-Whitney U: * p < 0.05, ** p < 0.01.