Table 1.
Summary of frequencies of genomic mutations commonly found in adult T-cell leukemia/lymphoma (ATLL) and other peripheral T-cell lymphoma (PTCL).
| Gene | ATLL Entire Japan [20] (n = 370) | ATLL North America [21] (n = 30) | ATLL Young Japanese [22] (n = 8) | PTCL-NOS [27] (n = 133) | AITL [27] (n = 26) | ALCL [27] (n = 23) | ENKTL [27] (n = 25) | HSTL [28] (n = 68) |
|---|---|---|---|---|---|---|---|---|
| PLCG1 | 36 | 0 | 0 | 8 | 8 | 0 | 0 | 6 |
| PRKCB | 33 | NE | 13 | 0 | 0 | 0 | 0 | NA |
| CCR4 | 29 | NE | 38 | 4 | 0 | 0 | 0 | 2 |
| CARD11 | 24 | 7 | 38 | 3 | 0 | 0 | 0 | 2 |
| STAT3 | 21 | 0 | 0 | 5 | 8 | 13 | 12 | 10 |
| TP53 | 18 | 23 | 13 | 17 | 0 | 9 | 12 | 10 |
| VAV1 | 18 | NE | 0 | 6 | 8 | 0 | 0 | NA |
| TBL1XR1 | 17 | 13 | 0 | 4 | 0 | 0 | 0 | NA |
| NOTCH1 | 15 | 20 | 25 | 5 | 0 | 0 | 0 | NA |
| GATA3 | 15 | 7 | 0 | 0 | 0 | 0 | 0 | NA |
| IRF4 | 14 | NE | 13 | 1 | 0 | 0 | 0 | 16 |
| FAS | 11 | 0 | 0 | 4 | 0 | 4 | 0 | NA |
| CCR7 | 11 | NE | 25 | 2 | 0 | 0 | 0 | NA |
| POT1 | 10 | 7 | 0 | 2 | 4 | 4 | 0 | NA |
| IRF2BP2 | 8 | NE | NE | 2 | 0 | 0 | 0 | NA |
| TET2 | 8 | 7 | 13 | 43 | 88 | 4 | 0 | 6 |
| RHOA | 8 | 3 | 13 | 26 | 81 | 0 | 0 | 2 |
| HLA-B | 6 | NE | 0 | 5 | 4 | 4 | 0 | NA |
| HNRNPA2B1 | 6 | NE | 0 | 0 | 0 | 4 | 0 | NA |
| EP300 | 6 | 20 | 0 | 2 | 0 | 0 | 8 | NA |
| CD58 | 5 | NE | 0 | 4 | 0 | 9 | 0 | 0 |
| GPR183 | 5 | NE | NE | 1 | 0 | 0 | 0 | NA |
| CSNK1A1 | 5 | NE | NE | 0 | 0 | 0 | 0 | NA |
| CSNK2B | 5 | NE | NE | 1 | 0 | 0 | 0 | NA |
| CBLB | 4 | NE | 0 | 0 | 0 | 0 | 0 | NA |
| FYN | 4 | NE | 13 | 2 | 0 | 0 | 0 | 3 |
| B2M | 4 | 0 | 0 | 5 | 8 | 0 | 0 | NA |
| SETD2 | 3 | 0 | 0 | 3 | 0 | 0 | 0 | 22 |
ATLL, adult T-cell leukemia/lymphoma; PTCL, peripheral T-cell lymphoma; PTCL-NOS, peripheral T-cell lymphoma, not otherwise specified; AITL, angioimmunoblastic T-cell lymphoma; ALCL, anaplastic large cell lymphoma; ENKTL, extranodal NK/T-cell lymphoma; HSTL, hepatosplenic T-cell lymphoma; NE, not evaluated; NA, not available.