Table 2.
Genomic alterations related to clinical findings in ATLL.
| Alteration | Targets | Clinical Outcome | Reference |
|---|---|---|---|
| CNA of cell cycle-related genes | Chronic type | Early acute transformation | [19] |
| Del of CD58 | Chronic type | Early acute transformation | [19] |
| PRKCB mutation | Aggressive type | Poor prognosis | [70] |
| Amp of PD-L1 | Aggressive type | Poor prognosis | [70] |
| IRF4 mutation | Indolent type | Poor prognosis | [70] |
| Amp; PD-L1 | Indolent type | Poor prognosis | [70] |
| Del; CDKN2A | Indolent type | Poor prognosis | [70] |
CNA, copy number alteration; Amp, amplification; Del, deletion.