Table 2.
Radiochemotherapy: Treatment completion rates and acute toxicity. For each parameter, the number of patients and, in brackets, the percentage are given. The statistical comparisons were performed with Chi-square test and Kruskal–Wallis test.
| Characteristics | 5‑Fluorouracil/ Cisplatin (n = 63) |
Carboplatin/ Paclitaxel (n = 27) |
p-Value |
|---|---|---|---|
| Radiotherapy | - | ||
| Received the planned dose without treatment breaks | 63 (100) | 27 (100) | |
| Chemotherapy | 0.01 | ||
| Received 100% of the planned cycles and dose | 51 (81.0) | 15 (55.6) | |
| Received < 100% of the planned cycles and/or dose | 12 (19.0) | 12 (44.4) | |
| Acute toxicity | |||
| Overall acute organ toxicity | 0.26 | ||
| ≥grade 3 | 16 (25.4) | 10 (37.0) | |
| <grade 3 | 47 (74.6) | 17 (63.0) | |
| Mucositis | 0.74 | ||
| 0 | 61 (96.8) | 24 (88.9) | |
| 1 | 1 (1.6) | 1 (3.7) | |
| 2 | 0 | 1 (3.7) | |
| 3 | 1 (1.6) | 1 (3.7) | |
| Dermatitis | 0.58 | ||
| 0 | 49 (77.8) | 25 (92.6) | |
| 1 | 13 (20.6) | 2 (7.4) | |
| 2 | 1 (1.6) | 0 | |
| Nausea | 0.75 | ||
| 0 | 46 (73.0) | 21 (77.8) | |
| 1 | 11 (17.5) | 2 (7.4) | |
| 2 | 6 (9.5) | 3 (11.1) | |
| 3 | 0 | 1 (3.7) | |
| Dysphagia | 0.18 | ||
| 0 | 2 (3.2) | 1 (3.7) | |
| 1 | 13 (20.6) | 8 (29.6) | |
| 2 | 30 (47.6) | 7 (25.9) | |
| 3 | 15 (23.8) | 11 (40.7) | |
| 4 | 3 (4.8) | 0 | |
| Hematologic toxicity | |||
| Overall hematologic toxicity | 0.04 | ||
| ≥grade 3 | 11 (17.5) | 10 (37.0) | |
| <grade 3 | 52 (82.5) | 17 (63.0) | |
| Anaemia | 0.40 | ||
| 0 | 10 (15.9) | 4 (14.8) | |
| 1 | 43 (68.3) | 18 (66.7) | |
| 2 | 6 (9.5) | 4 (14.8) | |
| 3 | 4 (6.3) | 1 (3.7) | |
| Leukopenia | 0.29 | ||
| 0 | 18 (28.6) | 3 (11.1) | |
| 1 | 21 (33.3) | 7 (25.9) | |
| 2 | 17 (27.0) | 7 (25.9) | |
| 3 | 6 (9.5) | 9 (33.3) | |
| 4 | 1 (1.6) | 1 (3.7) | |
| Thrombopenia | 0.53 | ||
| 0 | 40 (63.5) | 17 (63.0) | |
| 1 | 20 (31.7) | 8 (29.6) | |
| 2 | 2 (3.2) | 1 (3.7) | |
| 3 | 1 (1.6) | 1 (3.7) |