Table 1.
Clinical studies evaluating irreversible electroporation (IRE) in pancreatic cancer.
| Authors | Date | n | Cancer Stage and Size | Median OS (Months) | Location | Type of Study |
|---|---|---|---|---|---|---|
| Veldhuisen et al. [86] | 2020 | 52 | LAPC ≤ 4.5 cm | 17.2 | The Netherlands | Comparative |
| Ruarus et al. [87] | 2020 | 50 | LAPC ≤ 4.6 cm (n = 40) Post-surgical local recurrence (n = 10) |
LAPC: 17 Post-surgery local recurrence: 16 |
The Netherlands | Prospective single arm |
| He et al. [84] | 2020 | 32 | LAPC > 4 cm included | 24 | China | Propensity Score Matched analysis |
| Holland et al. [31] | 2019 | 152 | LAPC ≤ 5.5 cm | 30 | Multi-national | Prospective observational using patient registry |
| Liu et al. [88] | 2019 | 54 | LAPC (n = 28) metastatic PC (n = 24) |
LAPC: 20 metastatic PC: 14 |
China | Prospective |
| Flak et al. [30] | 2019 | 33 | LAPC ≤ 5 cm | 18 | Denmark | Prospective single arm |
| Mansson et al. [36] | 2019 | 24 | LAPC ≤ 3.5 cm | 13 | Sweden | Prospective |
| Leen et al. [33] | 2018 | 75 | LAPC ≤ 5 cm | 27 | United Kingdom | Prospective |
| Sugimoto et al. [89] | 2018 | 8 | LAPC ≤ 5 cm | 24 | Japan | Prospective |
| Huang et al. [90] | 2018 | 70 | LAPC≤ 5 cm | 22 | Taiwan | Retrospective |
| Vogel et al. [91] | 2017 | 15 | LAPC ≤ 5.5 cm | 16 | The Netherlands | Prospective |
| Scheffer et al. [42] | 2017 | 25 | LAPC ≤ cm | 17 | The Netherlands | Prospective |
| Narayanan et al. [40] | 2016 | 50 | LAP > 3 cm included | 27 | United States of America | Retrospective |
| Mansson et al. [35] | 2016 | 24 | LAPC ≤ 4.5 cm | 17.9 | Sweden | Prospective |
| Lambert et al. [52] | 2016 | 21 | LAPC ≤ 6.5 cm | 10 | Czech Republic | Retrospective |
| Martin et al. [37] | 2015 | 200 | LAPC | 24.9 | United States of America | Prospective |
| Kluger et al. [32] | 2015 | 50 | LAPC < 3 cm | 12 | United States of America | Prospective |
| Paeilla et al. [41] | 2015 | 10 | LAPC | 17 | Italy | Prospective |
| Martin et al. [38] | 2013 | 54 | LAPC | 20 | United States of America | Prospective with Propensity Score analysis |
Abbreviations: OS; Overall Survival, LAPC; Locally Advanced Pancreatic Cancer, PC; Pancreatic Cancer.