Table 1.

Locally applied agents for the treatment of OM listed from most to less commonly used.

Agent	Effect	Reference
Glycyrrhetinic acid/povidone/sodium hyaluronate gel	Adherence to the mouth mucosal surface, soothing oral lesions	[51]
L-glutamine	Counteraction of RT-induced metabolic deficiencies	[52]
Local anesthetics	Short-term relief of OM-associated pain (e.g., diphenhydramine, viscous xylocaine, lidocaine, and dyclonine hydrochloride)	[53]
Artificial saliva sprays	Alleviate mucosal dryness in mild cases of OM	[54]
Vitamin E (tocopherol)	Reduction of oral mucosa oxidative damage and, consequently, incidence of symptomatic OM	[55,56]
Sodium alginate	Reduction of OM-linked discomfort and OM severity	[57]
Zinc-L-carnosine	Physical barrier protection and repair of damaged areas	[58]
Polideoxyribonucleotide (PDRN)	Regenerative and anti-inflammatory device	[53,59,60]