Skip to main content
. 2021 Apr 9;12(4):549. doi: 10.3390/genes12040549

Figure 4.

Figure 4

Forest plot showing the association of significant miRNAs in our study with overall survival from various breast cancer studies, including METABRIC, TCGA, GSE40267, and GSE19783. Hazard ratios (HR) and confidence intervals are presented. The relative weight of each study and pooled HR estimates were calculated using the random-effects model. Blue squares represent hazard ratios of individual miRNAs in different breast cancer studies (METABRIC, TCGA, GSE40267, and GSE19783). Red diamonds indicate pooled effect estimates of miRNAs using the random-effects model and a 95% confidence interval. A hazard ratio (HR) >1 indicates that as the miRNA presence in breast cancer increases, risk increases, and thus survival decreases, whereas a risk ratio <1 indicates a reduced risk and increased survival. HR, hazard ratio; TCGA, The Cancer Genome Atlas; METABRIC, Molecular Taxonomy of Breast Cancer International Consortium; miRNA, microRNA. **—p-value < 0.05.