Table 2.
Top significant unique KEGG pathways enriched in TNBC at the 3′-UTR, corresponding to the significant terms of adjusted p-value (BH) ≤ 0.05.
| KEGG IDs | KEGG Terms | Top Hits | p-Value | Adjusted p-Value (BH) |
|---|---|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | 47 | 0 | 0 |
| hsa04110 | Cell cycle | 23 | 0 | 0 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 21 | 0 | 0 |
| hsa04218 | Cellular senescence | 31 | 0 | 0 |
| hsa04140 | Autophagy | 24 | 0 | 0 |
| hsa04917 | Prolactin signaling pathway | 17 | 0 | 0 |
| hsa04115 | p53 signaling pathway | 18 | 0 | 0 |
| hsa04066 | HIF-1 signaling pathway | 20 | 0.0001 | 0.0006 |
| hsa04668 | TNF signaling pathway | 20 | 0.0001 | 0.0006 |
| hsa01522 | Endocrine resistance | 18 | 0.0002 | 0.001 |
| hsa04210 | Apoptosis | 22 | 0.0002 | 0.001 |
| hsa04014 | Ras signaling pathway | 31 | 0.0003 | 0.0015 |
| hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 16 | 0.0005 | 0.0023 |
| hsa04010 | MAPK signaling pathway | 36 | 0.0005 | 0.0023 |
| hsa04068 | FoxO signaling pathway | 20 | 0.0008 | 0.0033 |
| hsa01524 | Platinum drug resistance | 13 | 0.0018 | 0.0064 |
| hsa04137 | Mitophagy | 12 | 0.002 | 0.0069 |
| hsa04012 | ErbB signaling pathway | 14 | 0.0023 | 0.0078 |
| hsa04370 | VEGF signaling pathway | 11 | 0.0029 | 0.0097 |
| hsa04150 | mTOR signaling pathway | 18 | 0.0162 | 0.0352 |
| hsa04310 | Wnt signaling pathway | 18 | 0.021 | 0.0426 |
| hsa04630 | JAK-STAT signaling pathway | 21 | 0.0034 | 0.0112 |
| hsa04350 | TGF-beta signaling pathway | 14 | 0.0052 | 0.0154 |
| hsa04152 | AMPK signaling pathway | 16 | 0.0076 | 0.0206 |
| hsa04390 | Hippo signaling pathway | 18 | 0.018 | 0.0387 |
| hsa04662 | B cell receptor signaling | 11 | 0.0229 | 0.0446 |
| hsa04660 | T cell receptor signaling | 13 | 0.0229 | 0.0446 |
BH, Benjamini–Hochberg; KEGG, Kyoto Encyclopedia of Genes and Genomes.