Table 5.

Effects of TT supplementation on serum nucleotide metabolites in mice fed HFD compared to the HFD control group.

Sub Pathway	Biochemical Name	HFD+TT800/HFD
Purine metabolism, xanthine/Inosine containing	Hypoxanthine	0.23
	Xanthine	0.41
	Xanthosine	0.53
	2′-Deoxyinosine	0.15
	Allantoin	0.85
Purine metabolism, Adenine containing	Adenosine-3′,5′-cyclic monophosphate (cAMP)	1.55
Purine metabolism, Guanine containing	7-Methylguanine	0.74
Purine Metabolism, Orotate containing	Dihydroorotate	1.55
Pyrimidine Metabolism, Uracil containing	Uridine	1.18

Metabolite values are expressed as the ratio of HFD+TT800/HFD which is the fold change of the treated HFD+TT800 group compared to the HFD control group. A ratio greater than 1 indicates a value larger for the treated group (HFD+TT800) and less than 1 the value for HFD+TT800 group is lower compared to the HFD control group. Green indicates fold reduction and red is for fold increase by TT supplementation with p ≤ 0.05 that was obtained from the Student’s t-test. Yellow indicates fold reduction and pink is for fold increase by TT supplementation with 0.05 < p < 0.1 that was obtained from the Student’s t-test.