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Illustration of the metabolism of galactose through the Leloir pathway. Galactose (Gal) is converted to Gal-1-P by the action of the enzymes GALM and GALK1. Gal-1-P is converted into Glc-1-P by GALT/GALE. Furthermore, Glc-1-P is converted to Glc-6-P (by PGM1 and PGM2), which follows the glycolytic pathway similar to glucose metabolism. Glc-1-P can also be converted to Glc-1,6-P2 (by PGM2L1), which is a master allosteric controller that can inhibit HK (glycolysis) and 6PGGDH (PPP).
